Dasatinib-induced Chylothorax in Chronic Myelogenous Leukemia in Pediatric Patient: Report of a Case and Review of Literature

被引:8
作者
Hickman, Kyle [1 ]
Diaz, Elizabeth [2 ]
Graham, Robert [2 ]
Adams, Roberta [1 ]
Ngwube, Alex [1 ]
机构
[1] Phoenix Childrens Hosp, Ctr Canc & Blood Disorders, 1919 E Thomas Rd, Phoenix, AZ 85016 USA
[2] Phoenix Childrens Hosp, Phoenix, AZ USA
关键词
dasatinib; chylthorax; pediatrics; CML;
D O I
10.1097/MPH.0000000000001619
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Dasatinib is a second-generation potent and efficacious oral tyrosine kinase inhibitor frequently used for imatinib-resistant or intolerant BCR-ABL-positive chronic myeloid leukemia and for Philadelphia chromosome-positive acute lymphocytic leukemia. Dasatinib is known to cause adverse pulmonary events such as chylothorax and has been described in the adult literature but not pediatric literature. The authors present a pediatric case of dasatinib-related chylothorax, subsequent management, and a review of the literature of adult cases with dasatinib-related chylothorax.
引用
收藏
页码:E665 / E667
页数:3
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