Telomere dynamics and telomerase activity in cell senescence and cancer

被引：27

作者：

Bacchetti, S

机构：

[1] Cancer Research Group, Department of Pathology, McMaster University, Hamilton

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1996年 / 7卷 / 01期

基金：

英国医学研究理事会;

关键词：

telomeres; telomerase; proliferative potential; senescence; cancer;

D O I：

10.1006/scdb.1996.0006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human somatic cells have a mortal phenotype that is under stringent genetic control and is dominant over unlimited proliferation. Reversal of this phenotype (immortality) may be required for tumour growth. Somatic cell division is accompanied by a decrease in telomeric DNA resulting in progressively shorter telomeres, a process that has been implicated in the control of the proliferative lifespan of cells. Conversely, telomere stabilization and expression of telomerase, the enzyme that elongates telomeric DNA, have been proposed as crucial to cell immortalization and tumour growth. This review discusses the data supporting this hypothesis, focusing on human cell, and addresses their implications for the management of cancer.

引用

页码：31 / 39

页数：9

共 72 条

[1] TELOMERIC REPEAT FROM T-THERMOPHILA CROSS HYBRIDIZES WITH HUMAN TELOMERES [J].