Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications

被引：263
作者：
Liu, Fuyao [1 ,2 ]
He, Xiuxia [3 ]
Chen, Hongda [1 ]
Zhang, Junping [1 ,3 ]
Zhang, Huimao [4 ]
Wang, Zhenxin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[3] Changchun Univ Sci & Technol, Sch Life Sci & Technol, Dept Biol Engn, Changchun 130022, Peoples R China
[4] Jilin Univ, Hosp 1, Dept Radiol, Changchun 130021, Peoples R China
来源：
NATURE COMMUNICATIONS | 2015年 / 6卷
关键词：
MULTIFUNCTIONAL NANOPARTICLES; CONTRAST AGENT; DRUG-DELIVERY; PLATFORM; SIZE; THERAPY; GALLATE; SYSTEM; SMART; DNA;
D O I：
10.1038/ncomms9003
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. However, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. In this study, pH-activated nanodots (termed Fe-CPNDs) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among Fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. The Fe-CPNDs exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. The Fe-CPNDs also exhibited pH-activatable magnetic resonance imaging contrast and outstanding photothermal performance. The features of Fe-CPNDs greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. Magnetic resonance imaging-guided photothermal therapy using Fe-CPNDs completely suppressed tumour growth. These findings demonstrate that Fe-CPNDs constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging.
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页数：9
相关论文
共 47 条
[1]   Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine [J].
Al-Jamal, Wafa' T. ;
Kostarelos, Kostas .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :1094-1104
[2]   Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities [J].
Cheng, Zhiliang ;
Al Zaki, Ajlan ;
Hui, James Z. ;
Muzykantov, Vladimir R. ;
Tsourkas, Andrew .
SCIENCE, 2012, 338 (6109) :903-910
[3]   The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles [J].
Cho, Minjung ;
Cho, Wan-Seob ;
Choi, Mina ;
Kim, Sueng Jun ;
Han, Beom Seok ;
Kim, Sheen Hee ;
Kim, Hyoung Ook ;
Sheen, Yhun Yhong ;
Jeong, Jayoung .
TOXICOLOGY LETTERS, 2009, 189 (03) :177-183
[4]   Renal clearance of quantum dots [J].
Choi, Hak Soo ;
Liu, Wenhao ;
Misra, Preeti ;
Tanaka, Eiichi ;
Zimmer, John P. ;
Ipe, Binil Itty ;
Bawendi, Moungi G. ;
Frangioni, John V. .
NATURE BIOTECHNOLOGY, 2007, 25 (10) :1165-1170
[5]   Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation [J].
Choi, Hak Soo ;
Frangioni, John V. .
MOLECULAR IMAGING, 2010, 9 (06) :291-310
[6]  
Choi HS, 2010, NAT NANOTECHNOL, V5, P42, DOI [10.1038/nnano.2009.314, 10.1038/NNANO.2009.314]
[7]  
Chou LYT, 2014, NAT NANOTECHNOL, V9, P148, DOI [10.1038/nnano.2013.309, 10.1038/NNANO.2013.309]
[8]   Nanoparticles: Take Only Pictures, Leave Only Footprints [J].
Choyke, Peter L. .
SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (260)
[9]   In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles [J].
Dai, Yunlu ;
Xiao, Haihua ;
Liu, Jianhua ;
Yuan, Qinghai ;
Ma, Ping'an ;
Yang, Dongmei ;
Li, Chunxia ;
Cheng, Ziyong ;
Hou, Zhiyao ;
Yang, Piaoping ;
Lin, Jun .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (50) :18920-18929
[10]   Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Drug Delivery [J].
Della Rocca, Joseph ;
Liu, Demin ;
Lin, Wenbin .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :957-968
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