Recent advances in carbohydrate-based cancer vaccines

被引：32

作者：

Jin, Ke-Tao ^{[1
]}

Lan, Huan-Rong ^{[2
]}

Chen, Xiao-Yi ^{[3
,4
]}

Wang, Shi-Bing ^{[3
,4
]}

Ying, Xiao-Jiang ^{[1
]}

Lin, Yan ^{[5
]}

Mou, Xiao-Zhou ^{[3
,4
]}

机构：

[1] Zhejiang Univ, Sch Med, Shaoxing Hosp, Dept Colorectal Surg,Shaoxing Peoples Hosp, Shaoxing 312000, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Shaoxing Hosp, Dept Breast & Thyroid Surg,Shaoxing Peoples Hosp, Shaoxing 312000, Zhejiang, Peoples R China

[3] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individualized Med Zheji, Hangzhou 310014, Zhejiang, Peoples R China

[4] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Clin Res Inst, Hangzhou 310014, Zhejiang, Peoples R China

[5] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Gastroenterol, Hangzhou 310014, Zhejiang, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2019年 / 41卷 / 6-7期

基金：

中国国家自然科学基金;

关键词：

Cancer vaccines; Carbohydrate; Immunotherapy; Tumor-associated carbohydrate antigens; ANTIGEN; 19-9; TALIMOGENE LAHERPAREPVEC; SIPULEUCEL-T; NEOADJUVANT THERAPY; PANCREATIC-CANCER; MELANOMA; GANGLIOSIDES; RESPONSES; SURVIVAL; DELIVERY;

D O I：

10.1007/s10529-019-02675-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal healthy cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Antibodies generated against the carbohydrate antigens partake in the inactivation of carbohydrate-decorated cancer cells, by slowing down tumor cell growth and inducing cancer cell apoptosis. Novel synthetic strategies for carbohydrate antigens have led to several synthetic cancer vaccine candidates. In the present review, we describe the latest progress in carbohydrate-based cancer vaccines and their clinical evaluation in various cancers.

引用

页码：641 / 650

页数：10

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