In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser, One-way ANOVA showed that the LILT which applied immediately or 15 min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome. (C) 2008 Elsevier B.V. All rights reserved.
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Tianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R ChinaTianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R China
Wang, Xue-yan
Ma, Wen-jiang
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Tianjin Med Univ, Hosp Eye, Tianjin 300384, Peoples R ChinaTianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R China
Ma, Wen-jiang
Liu, Chang-shan
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Tianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R ChinaTianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R China
Liu, Chang-shan
Li, Ying-xin
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Chinese Acad Med Sci, Beijing 100730, Peoples R China
Beijing Union Med Coll, Beijing, Peoples R ChinaTianjin Med Univ, Dept Paediat, Hosp 2, Tianjin 300211, Peoples R China