Attenuation of morphine withdrawal signs by low level laser therapy in rats

被引：8
|
作者：
Mirzaii-Dizgah, Iraj [2 ,3 ]
Ojaghi, Reza [1 ]
Sadeghipour-Roodsari, Hamid Reza [1 ]
Karimian, Seyed Morteza [1 ]
Sohanaki, Hamid [1 ]
机构：
[1] Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran 13145, Iran
[2] AJA Univ Med Sci, Sch Med, Dept Physiol, Tehran, Iran
[3] Qom Univ Med Sci, Clin Res Ctr, Qom, Iran
来源：
BEHAVIOURAL BRAIN RESEARCH | 2009年 / 196卷 / 02期
关键词：
Morphine; Opioid withdrawal; Low-intensity laser; LOW-POWER LASER; TERM NEUROLOGICAL DEFICITS; BRAIN ACETYLCHOLINE; CONTROLLED TRIAL; LOCUS-COERULEUS; NMDA RECEPTORS; IRRADIATION; CELLS; EFFICACY; BLIND;
D O I：
10.1016/j.bbr.2008.09.015
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser, One-way ANOVA showed that the LILT which applied immediately or 15 min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：268 / 270
页数：3
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