In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser, One-way ANOVA showed that the LILT which applied immediately or 15 min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome. (C) 2008 Elsevier B.V. All rights reserved.
机构:Univ Adelaide, Dept Anaesthesia & Intens Care, Adelaide, SA 5005, Australia
Bexis, S
Ong, J
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Univ Adelaide, Dept Anaesthesia & Intens Care, Adelaide, SA 5005, AustraliaUniv Adelaide, Dept Anaesthesia & Intens Care, Adelaide, SA 5005, Australia
Ong, J
White, J
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机构:Univ Adelaide, Dept Anaesthesia & Intens Care, Adelaide, SA 5005, Australia
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Albany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USAAlbany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USA
Panchal, V
Taraschenko, OD
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Albany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USAAlbany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USA
Taraschenko, OD
Maisonneuve, IM
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Albany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USAAlbany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USA
Maisonneuve, IM
Glick, SD
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Albany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USAAlbany Med Coll, Ctr Neuropharmacol & Neurosci MC136, Albany, NY 12208 USA