Haptoglobin in cerebrospinal fluid as a marker of infectious process in central nervous system

Haptoglobin is a transport protein and protects organism against iron loss and it should be involved in central nervous system infectious process. Patients and methods. Simultaneous serum and cerebrospinal fluid were obtained of 39 pediatric patients, 14 suffering from via meningoencephalitis and 25 from bacterial meningoencephalitis. Five control cases were examined too. Haptoglobin, IgG and albumin were quantified in both fluids by radial immunodiffusion Haptoglobin cerebrospinal fluid/serum ratio, haptoglobin index and haptoglobin/IgG index were calculated. Local IgG intrathecal synthesis was determined by reibergram. Results. Haptoglobin index was higher not statistically significant in viral meningoencephalitis in comparison with bacterial disease but both were statistically significant with respect to control group. Increased haptoglobin/IgG index were statistically significant in bacterial meningoencephalitis in relation with viral meningoencephalitis. There were no association between haptoglobin and polymorphonuclear cells count and globular sediment speed. Conclusion. Haptoglobin should be considered a relevant marker of central nervous system infections process.