A gene-driven approach to the identification of ENU mutants in the mouse

被引：128

作者：

Coghill, EL

Hugill, A

Parkinson, N

Davison, C

Glenister, P

Clements, S

Hunter, J

Cox, RD

Brown, SDM ^{[1
]}

机构：

[1] MRC, Mammalian Genet Unit, Harwell OX11 0RD, Berks, England

[2] UK Mouse Genome Ctr, Harwell OX11 0RD, Berks, England

[3] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

NATURE GENETICS | 2002年 / 30卷 / 03期

关键词：

D O I：

10.1038/ng847

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.

引用

页码：255 / 256

页数：2

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