Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

被引：17

作者：

James, Catherine P. ^{[1
,2
]}

Bajaj-Elliott, Mona ^{[2
]}

Abujaber, Razan ^{[3
]}

Forya, Frida ^{[1
]}

Klein, Nigel ^{[2
]}

David, Anna L. ^{[1
]}

Hollox, Edward J. ^{[3
]}

Peebles, Donald M. ^{[1
]}

机构：

[1] UCL Inst Womens Hlth, 86-96 Chenies Mews, London WC1E 6HX, England

[2] UCL Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England

[3] Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2018年 / 26卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/s41431-017-0061-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2 protein levels; however, our current understanding of the influence of copy number on mucosal AMP function remains limited. This study explores the relationship between HBD copy number, cervicovaginal HBD2 protein levels and antimicrobial activity in 203 women with risk factors for preterm birth. We provide evidence that suggests HBD copy number modulates cervical antimicrobial immunity.

引用

页码：434 / 439

页数：6

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