Expedient synthesis of the pentasaccharide repeating unit of the O-antigen of Escherichia coli O86 and its conformational analysis

被引：4

作者：

Bhaumik, Ishani ^{[1
]}

Kar, Rajiv Kumar ^{[2
]}

Bhunia, Anirban ^{[2
]}

Misra, Anup Kumar ^{[1
]}

机构：

[1] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, India

[2] Bose Inst, Dept Biophys, P-1-12,CIT Scheme 7 M, Kolkata 700054, India

来源：

GLYCOCONJUGATE JOURNAL | 2016年 / 33卷 / 06期

关键词：

Lipopolysaccharides; Glycosylations; Antigens; Escherichia coli; Molecular dynamics (MD) simulation; CONCISE SYNTHESIS; POLYSACCHARIDE; LIPOPOLYSACCHARIDE; GLYCOSYLATION; HCLO4-SIO2; EFFICIENT;

D O I：

10.1007/s10719-016-9687-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of the pentasaccharide with a 2-aminoethyl linker attached to the reducing end corresponding to the cell wall O-antigen of Escherichia coli O86 strain is reported. The synthetic strategy involves sequential glycosylation of suitably protected monosaccharide intermediates under similar glycosylation reaction conditions. Thioglycosides have been used as glycosyl donor throughout the synthetic strategy. Conformational analysis of the synthesized pentasaccharide has been carried out using 2D ROESY NMR spectral analysis and all atom explicit molecular dynamics (MD) simulation technique.

引用

页码：887 / 896

页数：10

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