Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections

被引：67

作者：

Hanson, Kimberly E. ^{[1
,2
]}

Couturier, Marc Roger ^{[2
]}

机构：

[1] Univ Utah, Div Infect Dis, Salt Lake City, UT USA

[2] Univ Utah, Div Clin Microbiol, Salt Lake City, UT USA

来源：

CLINICAL INFECTIOUS DISEASES | 2016年 / 63卷 / 10期

基金：

美国国家卫生研究院;

关键词：

molecular diagnostics; respiratory; gastrointestinal; meningoencephalitis; REAL-TIME PCR; COMMUNITY-ACQUIRED PNEUMONIA; POLYMERASE-CHAIN-REACTION; RAPID DETECTION; MULTICENTER EVALUATION; CLOSTRIDIUM-DIFFICILE; PEDIATRIC-PATIENTS; STOOL SPECIMENS; PATHOGEN PANEL; C; COLI;

D O I：

10.1093/cid/ciw494

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development and implementation of highly multiplexed molecular diagnostic tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a variety of pathogens directly in clinical specimens. Current US Food and Drug Administration-approved multiplex panels target multiple different organisms simultaneously and can identify the most common pathogens implicated in respiratory viral, gastrointestinal, or central nervous system infections. This review summarizes the test characteristics of available assays, highlights the advantages and limitations of multiplex technology for infectious diseases, and discusses potential utilization of these new tests in clinical practice.

引用

页码：1361 / 1367

页数：7

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