Chemical Constituents from the Fungus Antrodia cinnamomea

被引：0

作者：

Wu, Ming-Der ^{[1
]}

Cheng, Ming-Jen ^{[1
]}

Chen, Yen-Lin ^{[1
]}

Hsun-Hsuo-Chang ^{[2
,3
,4
]}

Kuo, Yueh-Hsiung ^{[5
,6
,7
,8
]}

Lin, Chih-Chuan ^{[9
]}

Wu, Ho-Cheng ^{[4
]}

机构：

[1] FIRDI, BCRC, Hsinchu 300, Taiwan

[2] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Ctr Infect Dis & Canc Res CICAR, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[5] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[6] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan

[7] China Med Univ, Chinese Med Res Ctr, Taichung 404, Taiwan

[8] China Med Univ, Res Ctr Chinese Herbal Med, Taichung 404, Taiwan

[9] Natl Chung Hsing Univ, Coll Agr & Nat Resources, Expt Forest Management Off, Taichung 402, Taiwan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 01期

关键词：

Antrodia cinnamomea; Polyporaceae; Benzenoid; Cytotoxicity; CAMPHORATA; MYCELIUM; DERIVATIVES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2-methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 M in vitro.

引用

页码：129 / 130

页数：2

共 12 条

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