The Molecular Link from Diet to Cancer Cell Metabolism

被引：62

作者：

Bose, Shree ^{[1
]}

Allen, Annamarie E. ^{[1
]}

Locasale, Jason W. ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] North Carolina State Univ, Dept Mol & Struct Biochem, Raleigh, NC 27695 USA

来源：

MOLECULAR CELL | 2020年 / 78卷 / 06期

基金：

美国国家卫生研究院;

关键词：

AMINO-ACID-METABOLISM; CALORIE RESTRICTION; OXIDATIVE STRESS; TUMOR-GROWTH; LOW-CARBOHYDRATE; GUT MICROBIOME; ASPARAGINE; SERINE; PROLIFERATION; DEPENDENCY;

D O I：

10.1016/j.molcel.2020.05.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation. These demands lead to differential requirements in energy, biosynthetic precursors, and signaling intermediates. Both genetic programs arising from oncogenic events and transcriptional programs and epigenomic events are important in providing the necessary metabolic network activity. Accumulating evidence has established that environmental factors play a major role in shaping cancer cell metabolism. For metabolism, diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. In this review, we discuss these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism.

引用

页码：1034 / 1044

页数：11

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