Hybrid ultra-low-field MRI and magnetoencephalography system based on a commercial whole-head neuromagnetometer

被引：83

作者：

Vesanen, Panu T. ^{[1
]}

Nieminen, Jaakko O. ^{[1
]}

Zevenhoven, Koos C. J. ^{[1
]}

Dabek, Juhani ^{[1
]}

Parkkonen, Lauri T. ^{[1
,2
]}

Zhdanov, Andrey V. ^{[1
,3
]}

Luomahaara, Juho ^{[4
,5
]}

Hassel, Juha ^{[4
]}

Penttila, Jari ^{[5
]}

Simola, Juha ^{[2
]}

Ahonen, Antti I. ^{[2
]}

Makela, Jyrki P. ^{[3
]}

Ilmoniemi, Risto J. ^{[1
]}

机构：

[1] Aalto Univ, Sch Sci, Dept Biomed Engn & Computat Sci, Espoo, Finland

[2] Elekta Oy, Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, HUSLAB, BioMag Lab, Helsinki, Finland

[4] VTT Tech Res Ctr Finland, Espoo, Finland

[5] Aivon Oy, Espoo, Finland

来源：

MAGNETIC RESONANCE IN MEDICINE | 2013年 / 69卷 / 06期

基金：

芬兰科学院;

关键词：

ultra-low-field MRI; magnetoencephalography; MEG-MRI; superconducting quantum interference device; MICROTESLA MRI; MU-T; BRAIN; CONTRAST; NOISE;

D O I：

10.1002/mrm.24413

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Ultra-low-field MRI uses microtesla fields for signal encoding and sensitive superconducting quantum interference devices for signal detection. Similarly, modern magnetoencephalography (MEG) systems use arrays comprising hundreds of superconducting quantum interference device channels to measure the magnetic field generated by neuronal activity. In this article, hybrid MEG-MRI instrumentation based on a commercial whole-head MEG device is described. The combination of ultra-low-field MRI and MEG in a single device is expected to significantly reduce coregistration errors between the two modalities, to simplify MEG analysis, and to improve MEG localization accuracy. The sensor solutions, MRI coils (including a superconducting polarizing coil), an optimized pulse sequence, and a reconstruction method suitable for hybrid MEG-MRI measurements are described. The performance of the device is demonstrated by presenting ultra-low-field-MR images and MEG recordings that are compared with data obtained with a 3T scanner and a commercial MEG device. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：1795 / 1804

页数：10

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