Generalized lymphatic malformation with chylothorax: Long-term management of a highly morbid condition in a pediatric patient

被引：14

作者：

Chen, Wendy ^{[1
,2
]}

Adams, Denise ^{[3
]}

Patel, Manish ^{[4
]}

Gupta, Anita ^{[5
]}

Dasgupta, Roshni ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Dept Pediat Gen & Thorac Surg, Cincinnati, OH USA

[2] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[3] Cincinnati Childrens Hosp Med Ctr, Dept Hematol & Oncol, Cincinnati, OH USA

[4] Cincinnati Childrens Hosp Med Ctr, Dept Intervent Radiol, Cincinnati, OH USA

[5] Cincinnati Childrens Hosp Med Ctr, Dept Pathol, Cincinnati, OH USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2013年 / 48卷 / 03期

关键词：

Chylothorax; Generalized lymphatic malformation; GORHAMS-SYNDROME; ENDOTHELIAL-CELLS; DISEASE; GROWTH; SURVIVAL; CHILDREN; VEGFR-3; THERAPY; CANCER;

D O I：

10.1016/j.jpedsurg.2013.01.017

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Generalized lymphatic malformation (GLM) often causes chylothorax, which can be a highly morbid condition. Chylothorax in a pediatric patient with a lymphangiogenic disorder may be especially resistant to therapy, requiring more aggressive measures. We discuss the complex ongoing long-term management of a pediatric patient with GLM who presented with massive, persistent left chylothorax, which resolved by surgical ligation of the thoracic duct and medical management. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：E9 / E12

页数：4

共 22 条

[1] Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer [J].

Barnes, N. L. P. ;

Warnberg, F. ;

Farnie, G. ;

White, D. ;

Jiang, W. ;

Anderson, E. ;

Bundred, N. J. .

BRITISH JOURNAL OF CANCER, 2007, 96 (04) :575-582

[2] Chylothorax complicating Gorham's disease [J].

Chavanis, N ;

Chaffanjon, P ;

Frey, G ;

Vottero, G ;

Brichon, PY .

ANNALS OF THORACIC SURGERY, 2001, 72 (03) :937-939

[3] GORHAMS SYNDROME - A CASE-REPORT AND REVIEW OF THE LITERATURE [J].

CHOMA, ND ;

BISCOTTI, CV ;

BAUER, TW ;

MEHTA, AC ;

LICATA, AA .

AMERICAN JOURNAL OF MEDICINE, 1987, 83 (06) :1151-1156

[4] Lymphangiography in the Diagnosis and Localization of Various Chyle Leaks [J].

Deso, Steve ;

Ludwig, Benjamin ;

Kabutey, Nii-Kabu ;

Kim, Ducksoo ;

Guermazi, Ali .

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 35 (01) :117-126

[5] Progesterone receptors identified in vascular malformations of the head and neck [J].

Duyka, Landon J. ;

Fan, Chun Y. ;

Coviello-Malle, Jean M. ;

Buckmiller, Lisa ;

Suen, James Y. .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2009, 141 (04) :491-495

[6] CHYLOTHORAX - A REVIEW OF 18 CASES [J].

FAIRFAX, AJ ;

MCNABB, WR ;

SPIRO, SG .

THORAX, 1986, 41 (11) :880-885

[7] Chyothorax associated with massive osteolysis (Gorham's syndrome) [J].

Fujiu, K ;

Kanno, R ;

Suzuki, H ;

Nakamura, N ;

Gotoh, M .

ANNALS OF THORACIC SURGERY, 2002, 73 (06) :1956-1957

[8]

GOORWITCH J, 1955, J THORAC SURG, V29, P467

[9] Sirolimus for the Treatment of Complicated Vascular Anomalies in Children [J].

Hammill, Adrienne M. ;

Wentzel, MarySue ;

Gupta, Anita ;

Nelson, Stephen ;

Lucky, Anne ;

Elluru, Ravi ;

Dasgupta, Roshni ;

Azizkhan, Richard G. ;

Adams, Denise M. .

PEDIATRIC BLOOD & CANCER, 2011, 57 (06) :1018-1024

[10] Lymphatic and venous malformation or lymphangiohemangioma" of the anterior mediastinum: Case report and literature review" [J].

Kadota Y. ;

Utsumi T. ;

Kawamura T. ;

Inoue M. ;

Sawabata N. ;

Minami M. ;

Okumura M. .

General Thoracic and Cardiovascular Surgery , 2011, 59 (8) :575-578

← 1 2 3 →