Analgetic effect of docosahexaenoic acid is mediated by modulating the microglia activity in the dorsal root ganglia in a rat model of neuropathic pain

被引：21

作者：

Manzhulo, Igor V. ^{[1
,2
]}

Ogurtsova, Olga S. ^{[1
]}

Lamash, Nina E. ^{[1
]}

Latyshev, Nikolay A. ^{[1
]}

Kasyanov, Sergey P. ^{[1
]}

Dyuizen, Inessa V. ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, AV Zhirmunsky Inst Marine Biol, Vladivostok 690059, Russia

[2] Far Eastern Fed Univ, Sch Biomed, Vladivostok 690950, Russia

来源：

ACTA HISTOCHEMICA | 2015年 / 117卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

Dorsal root ganglia; Docosahexaenoic acid; Microglia; CCI; Apoptosis; Satellite cells; PERIPHERAL-NERVE INJURY; SATELLITE GLIAL-CELLS; TRIGEMINAL GANGLION; SPINAL-CORD; SCIATIC-NERVE; TNF-ALPHA; NEURONS; MOUSE; P53; INFLAMMATION;

D O I：

10.1016/j.acthis.2015.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The analgetic activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied using a chronic constriction injury (CCI) model in rats, and the dynamics of iba-1 (+) microglia/macrophages in the dorsal root ganglia (DRG) were characterized. DHA reduced the intensity and duration of neurogenic pain. The application of DHA led to an earlier stabilization of weight bearing in the incapacitance test and prevented the development of cold allodynia and degenerative changes in tissues of the denervated limb. DHA treatment significantly reduced satellite glia reaction and expression of the pro-apoptotic p53 protein in the DRG. Thus, DHA's anti-pain effect may be a result of the modulation of microglia/macrophages activity and the development of neuroprotective effects at the level of the dorsal root ganglia. (C) 2015 Elsevier GmbH. All rights reserved.

引用

页码：659 / 666

页数：8

共 53 条

[21] Caspase signalling in neuropathic and inflammatory pain in the rat
Joseph, EK
Levine, JD
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (11) : 2896 - 2902
[22] Docosanoids are multifunctional regulators of neural cell integrity and fate: Significance in aging and disease
Kherjee, P. K. Mu.
Chawla, A.
Loayza, M. S.
Bazan, N. G.
[J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2007, 77 (5-6): : 233 - 238
[23] Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord
Kigerl, Kristina A.
Gensel, John C.
Ankeny, Daniel P.
Alexander, Jessica K.
Donnelly, Dustin J.
Popovich, Phillip G.
[J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (43) : 13435 - 13444
[24] Minocycline selectively inhibits M1 polarization of microglia
Kobayashi, K.
Imagama, S.
Ohgomori, T.
Hirano, K.
Uchimura, K.
Sakamoto, K.
Hirakawa, A.
Takeuchi, H.
Suzumura, A.
Ishiguro, N.
Kadomatsu, K.
[J]. CELL DEATH & DISEASE, 2013, 4 : e525 - e525
[25] Korzhevskii D E, 2012, Morfologiia, V141, P28
[26] Microglial cell population dynamics in the injured adult central nervous system
Ladeby, R
Wirenfeldt, M
Garcia-Ovejero, D
Fenger, C
Dissing-Olesen, L
Dahnau, I
Finsen, B
[J]. BRAIN RESEARCH REVIEWS, 2005, 48 (02) : 196 - 206
[27] Concentration and purification of polyunsaturated fatty acids from squid liver processing wastes
Latyshev, Nikolay A.
Ermolenko, Ekaterina V.
Kasyanov, Sergey P.
[J]. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2014, 116 (11) : 1608 - 1613
[28] Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Liao, Bing
Zhao, Weihua
Beers, David R.
Henkel, Jenny S.
Appel, Stanley H.
[J]. EXPERIMENTAL NEUROLOGY, 2012, 237 (01) : 147 - 152
[29] A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
Lukiw, WJ
Cui, JG
Marcheselli, VL
Bodker, M
Botkjaer, A
Gotlinger, K
Serhan, CN
Bazan, NG
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) : 2774 - 2783
[30] Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates
Malmberg, AB
Basbaum, AI
[J]. PAIN, 1998, 76 (1-2) : 215 - 222

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