Analgetic effect of docosahexaenoic acid is mediated by modulating the microglia activity in the dorsal root ganglia in a rat model of neuropathic pain

被引：21
作者：
Manzhulo, Igor V. [1 ,2 ]
Ogurtsova, Olga S. [1 ]
Lamash, Nina E. [1 ]
Latyshev, Nikolay A. [1 ]
Kasyanov, Sergey P. [1 ]
Dyuizen, Inessa V. [1 ]
机构：
[1] Russian Acad Sci, Far Eastern Branch, AV Zhirmunsky Inst Marine Biol, Vladivostok 690059, Russia
[2] Far Eastern Fed Univ, Sch Biomed, Vladivostok 690950, Russia
来源：
ACTA HISTOCHEMICA | 2015年 / 117卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
Dorsal root ganglia; Docosahexaenoic acid; Microglia; CCI; Apoptosis; Satellite cells; PERIPHERAL-NERVE INJURY; SATELLITE GLIAL-CELLS; TRIGEMINAL GANGLION; SPINAL-CORD; SCIATIC-NERVE; TNF-ALPHA; NEURONS; MOUSE; P53; INFLAMMATION;
D O I：
10.1016/j.acthis.2015.07.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The analgetic activity of docosahexaenoic acid (DHA, 22:6 n-3) was studied using a chronic constriction injury (CCI) model in rats, and the dynamics of iba-1 (+) microglia/macrophages in the dorsal root ganglia (DRG) were characterized. DHA reduced the intensity and duration of neurogenic pain. The application of DHA led to an earlier stabilization of weight bearing in the incapacitance test and prevented the development of cold allodynia and degenerative changes in tissues of the denervated limb. DHA treatment significantly reduced satellite glia reaction and expression of the pro-apoptotic p53 protein in the DRG. Thus, DHA's anti-pain effect may be a result of the modulation of microglia/macrophages activity and the development of neuroprotective effects at the level of the dorsal root ganglia. (C) 2015 Elsevier GmbH. All rights reserved.
引用
收藏
页码：659 / 666
页数：8
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