Mechanisms of body eight fluctuations in Parkinson's disease

被引：75

作者：

Kistner, Andrea ^{[1
,2
]}

Lhommee, Eugenie ^{[1
,2
]}

Krack, Paul ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Grenoble, Dept Psychiat & Neurol, Movement Disorder Unit, Grenoble, France

[2] Grenoble Inst Neurosci, INSERM, U836, Equipe 11, Grenoble, France

[3] Univ Grenoble 1, Grenoble, France

来源：

FRONTIERS IN NEUROLOGY | 2014年 / 5卷

关键词：

Parkinson's disease; body weight; eating behavior; DBS; dopamine; binge-eating disorder; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; IMPULSE CONTROL DISORDERS; INCREASED ENERGY-EXPENDITURE; WEIGHT-GAIN; MASS INDEX; COMPULSIVE BEHAVIORS; DORSAL STRIATUM; RISK-FACTORS; DEPRESSIVE-SYMPTOMS;

D O I：

10.3389/fneur.2014.00084

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Typical body weight changes are known to occur in Parkinson's disease (PD). Weight loss has been reported in early stages as well as in advanced disease and malnutrition may worsen the clinical state of the patient. On the other hand, an increasing number of patients show weight gain under dopamine replacement therapy or after surgery. These weight changes are multifactorial and involve changes in energy expenditure, perturbation of homeostatic control, and eating behavior modulated by dopaminergic treatment. Comprehension of the different mechanisms contributing to body weight is a prerequisite for the management of body weight and nutritional state of an individual PD patient. This review summarizes the present knowledge and highlights the necessity of evaluation of body weight and related factors, as eating behavior, energy intake, and expenditure in PD.

引用

页数：15

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