Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti†

被引：161

作者：

Cornillot, Emmanuel ^{[1
]}

Hadj-Kaddour, Kamel ^{[1
]}

Dassouli, Amina ^{[1
]}

Noel, Benjamin ^{[2
,3
]}

Ranwez, Vincent ^{[4
,5
]}

Vacherie, Benoit ^{[2
,3
]}

Augagneur, Yoann ^{[6
]}

Bres, Virginie ^{[1
]}

Duclos, Aurelie ^{[2
,3
]}

Randazzo, Sylvie ^{[1
]}

Carcy, Bernard ^{[1
]}

Debierre-Grockiego, Francoise ^{[7
,8
]}

Delbecq, Stephane ^{[1
]}

Moubri-Menage, Karina ^{[1
]}

Shams-Eldin, Hosam ^{[9
]}

Usmani-Brown, Sahar ^{[6
]}

Bringaud, Frederic ^{[10
]}

Wincker, Patrick ^{[2
,3
]}

Vivares, Christian P. ^{[11
]}

Schwarz, Ralph T. ^{[9
]}

Schetters, Theo P. ^{[12
]}

Krause, Peter J. ^{[13
,14
]}

Gorenflot, Andre ^{[1
]}

Berry, Vincent ^{[15
]}

Barbe, Valerie ^{[2
,3
]}

Ben Mamoun, Choukri ^{[6
]}

机构：

[1] Univ Montpellier I, UFR Pharm, EA4558, LBCM, F-34093 Montpellier 5, France

[2] Genoscope CEA, F-91057 Evry, France

[3] Univ Evry, CNRS, UMR 8030, F-91057 Evry, France

[4] Univ Montpellier 2, CNRS, UMR 5554, ISEM,Inst Sci Evolut, F-34095 Montpellier 5, France

[5] Montpellier SupAgro, UMR AGAP, F-34398 Montpellier 5, France

[6] Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT 06520 USA

[7] Univ Tours, Infectiol & Sante Publ UMR1282, F-37000 Tours, France

[8] INRA, F-37380 Nouzilly, France

[9] Univ Marburg, Zentrum Hyg & Infekt Biol, Inst Virol, D-35043 Marburg, Germany

[10] Univ Bordeaux Segalen, CNRS, UMR 5536, Ctr Resonance Magnet Syst Biol,RMSB, F-33076 Bordeaux, France

[11] Univ Blaise Pascal, Clermont Univ, Lab Microorganismes Genome & Environm, F-63000 Clermont Ferrand, France

[12] Intervet Schering Plough Anim Hlth, Microbiol R&D Dept, NL-5830 AA Boxmeer, Netherlands

[13] Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA

[14] Yale Univ, Sch Med, New Haven, CT 06520 USA

[15] Univ Montpellier 2, CNRS, UMR 5506, Equipe Methodes & Algorithmes Bioinformat,LIRMM, F-34095 Montpellier, France

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / 18期

基金：

美国国家卫生研究院;

关键词：

ISOPRENOID BIOSYNTHESIS; LACTATE-DEHYDROGENASE; SIGNAL-TRANSDUCTION; HOST-CELLS; GENE; PARASITES; PLASMODIUM; EVOLUTION; PROTEIN; ALIGNMENT;

D O I：

10.1093/nar/gks700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have sequenced the genome of the emerging human pathogen Babesia microti and compared it with that of other protozoa. B. microti has the smallest nuclear genome among all Apicomplexan parasites sequenced to date with three chromosomes encoding similar to 3500 polypeptides, several of which are species specific. Genome-wide phylogenetic analyses indicate that B. microti is significantly distant from all species of Babesidae and Theileridae and defines a new clade in the phylum Apicomplexa. Furthermore, unlike all other Apicomplexa, its mitochondrial genome is circular. Genome-scale reconstruction of functional networks revealed that B. microti has the minimal metabolic requirement for intraerythrocytic protozoan parasitism. B. microti multigene families differ from those of other protozoa in both the copy number and organization. Two lateral transfer events with significant metabolic implications occurred during the evolution of this parasite. The genomic sequencing of B. microti identified several targets suitable for the development of diagnostic assays and novel therapies for human babesiosis.

引用

页码：9102 / 9114

页数：13

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