Reaction of the lithio-derivative of methoxy allene with SAMP-hydrazones:: Access to enantiopure 3-pyrrolines

被引：38

作者：

Breuil-Desvergnes, V ^{[1
]}

Compain, P ^{[1
]}

Vatèle, JM ^{[1
]}

Goré, J ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, Lab Chim Organ 1, CPE Lyon, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(99)00934-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Lithio methoxy allene reacts with SAMP-hydrazones to give alpha-allenyl hydrazines 5 or 3-methoxy-3-pyrrolines 6 depending on the nature of the solvent. Both compounds have been obtained with d.e. greater than or equal to 99%. Hydrogenolysis of the N-N bond of 6 affords the pyrroline 7 in enantiopure form. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5009 / 5012

页数：4

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