Effects of mild traumatic brain injury and post-traumatic stress disorder on resting-state default mode network connectivity

被引：20
作者：
Santhanam, Priya [1 ]
Wilson, Steffanie H. [2 ]
Oakes, Terrence R. [3 ]
Weaver, Lindell K. [4 ,5 ,6 ]
机构：
[1] Lovelace Biomed Res, Albuquerque, NM USA
[2] Emmes Corp, 401 N Washington St,Suite 700, Rockville, MD 20850 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA
[4] Intermt Med Ctr, Div Hyperbar Med, Murray, UT USA
[5] Intermt LDS Hosp, Div Hyperbar Med, Salt Lake City, UT USA
[6] Univ Utah, Sch Med, Dept Med, Salt Lake, CT USA
来源：
BRAIN RESEARCH | 2019年 / 1711卷
关键词：
Traumatic brain injury; Post-traumatic stress disorder; Default mode network; Independent component analysis; Medial prefrontal cortex; Posterior cingulate cortex; FUNCTIONAL CONNECTIVITY; STRUCTURAL CONNECTIVITY; SUSTAINED ATTENTION; ALZHEIMERS-DISEASE; HYPERBARIC-OXYGEN; MEMORY RETRIEVAL; CINGULATE CORTEX; PARIETAL CORTEX; SYMPTOMS; IRAQ;
D O I：
10.1016/j.brainres.2019.01.015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common outcomes for service members. Abnormal connectivity within neural networks has been reported in the resting brain of mTBI and PTSD patients, respectively; however, the potential role of PTSD in changes to neural networks following injury has not been studied in detail. Using a data-driven approach, the present analysis aimed to elucidate resting state functional connectivity in the default mode network (DMN) in those with mTBI only and those with comorbid mTBI and PTSD. A secondary analysis focused on distinct contributions by the anterior and posterior DMN components. Group-level independent component analysis was used to identify the DMN, and a dual-regression method was utilized to measure connectivity within the overall network and its anterior (medial prefrontal cortex) and posterior (posterior cingulate cortex) nodes. Connectivity within the overall DMN was significantly higher for the mTBI only group (p = 0.001), as compared to controls and mTBI + PTSD. For all subjects with mTBI, network connectivity correlated inversely with PTSD checklist score (p < 0.05). Additionally, distinct associations (p < 0.05) between medial prefrontal cortex connectivity and PTSD symptoms and, separately, posterior cingulate cortex connectivity and mTBI-related cognitive deficits were found. To our knowledge, this is the first study to report a differential relationship between DMN components and both post-traumatic symptoms and cognitive outcomes.
引用
收藏
页码：77 / 82
页数：6
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