Intestinal uptake and biodistribution of novel polymeric micelles after oral administration

被引：86
|
作者：
Mathot, F
van Beijsterveldt, L
Préat, V
Brewster, M
Ariën, A
机构：
[1] Catholic Univ Louvain, Dept Pharmaceut Technol, B-1200 Brussels, Belgium
[2] Johnson & Johnson Pharmaceut Res & Dev, Div Janssen Pharmaceut, B-2340 Beerse, Belgium
来源：
JOURNAL OF CONTROLLED RELEASE | 2006年 / 111卷 / 1-2期
关键词：
self-assembling polymeric micelles; Caco-2; risperidone; oral delivery; biodistribution; mmePEG(750)P(CL-co-TMC);
D O I：
10.1016/j.jconrel.2005.11.012
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To determine the fate of polymeric micelles after oral administration, we investigated the possible transport of polymeric micelles across Caco-2 monolayers and their biodistribution in rats after per os administration of [C-14]-labelled mmePEG(750)P(CL-co-TMC) micelles containing risperidone (BCS Class II drug). mmePEG(750)P(CL-co-TMC) was able to cross Caco-2 monolayer via a saturable transport mechanism. The oral bioavailability of the polymer was 40%. Polymeric micelles based on mmePEG(750)P(CL-co-TMC) showed very low clearance by the reticuloendothelial system (RES) and a renal excretion. A sustained release of risperidone was observed. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：47 / 55
页数：9
相关论文
共 50 条
  • [31] Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice
    Yousefi, Gholamhossein
    Shafaati, Alireza
    Zarghi, Afshin
    Foroutan, Seyed Mohsen
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 : 111 - 123
  • [32] Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery
    Joshi, Garima
    Kumar, Abhinesh
    Sawant, Krutika
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 60 : 80 - 89
  • [33] The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles
    Attia, Amalina B. Ebrahim
    Yang, Chuan
    Tan, Jeremy P. K.
    Gao, Shujun
    Williams, David F.
    Hedrick, James L.
    Yang, Yi-Yan
    BIOMATERIALS, 2013, 34 (12) : 3132 - 3140
  • [34] Smart pH-responsive polymeric micelles for programmed oral delivery of insulin
    Hu, Wen Yao
    Wu, Zhi Min
    Yang, Qian Qian
    Liu, Yue Jin
    Li, Juan
    Zhang, Can Yang
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 183
  • [35] Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
    Semete, Boitumelo
    Booysen, Laetitia
    Kalombo, Lonji
    Ramalapa, Bathabile
    Hayeshi, Rose
    Swai, Hulda S.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 424 (1-2) : 115 - 120
  • [36] Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier
    Mathot, Frederic
    Rieux, A. Des
    Arien, A.
    Schneider, Y-J.
    Brewster, M.
    Preat, V.
    JOURNAL OF CONTROLLED RELEASE, 2007, 124 (03) : 134 - 143
  • [37] Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method
    Laan, Adrianus C.
    Santini, Costanza
    Jennings, Laurence
    de Jong, Marion
    Bernsen, Monique R.
    Denkova, Antonia G.
    EJNMMI RESEARCH, 2016, 6 : 1 - 10
  • [38] In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
    Liu, Jia
    Li, Hongxia
    Chen, Daquan
    Jin, Xiang
    Zhao, Xiaoliang
    Zhang, Can
    Ping, Qineng
    DRUG DELIVERY, 2011, 18 (03) : 181 - 189
  • [39] Pharmacokinetics and biodistribution of paclitaxel-loaded Pluronic P105/L101 mixed polymeric micelles
    Wang, Yongzhong
    Li, Yajuan
    Wang, Qingsong
    Wu, Jiang
    Fang, Xiaoling
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, 128 (06): : 941 - 950
  • [40] The synthesis of novel taxoids for oral administration
    Jing, Yun-rong
    Zhou, Wei
    Li, Wan-liang
    Zhao, Lin-xiang
    Wang, Yong-feng
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (01) : 194 - 203
12345