Intestinal uptake and biodistribution of novel polymeric micelles after oral administration

被引：87

作者：

Mathot, F

van Beijsterveldt, L

Préat, V

Brewster, M

Ariën, A

机构：

[1] Catholic Univ Louvain, Dept Pharmaceut Technol, B-1200 Brussels, Belgium

[2] Johnson & Johnson Pharmaceut Res & Dev, Div Janssen Pharmaceut, B-2340 Beerse, Belgium

来源：

JOURNAL OF CONTROLLED RELEASE | 2006年 / 111卷 / 1-2期

关键词：

self-assembling polymeric micelles; Caco-2; risperidone; oral delivery; biodistribution; mmePEG(750)P(CL-co-TMC);

D O I：

10.1016/j.jconrel.2005.11.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To determine the fate of polymeric micelles after oral administration, we investigated the possible transport of polymeric micelles across Caco-2 monolayers and their biodistribution in rats after per os administration of [C-14]-labelled mmePEG(750)P(CL-co-TMC) micelles containing risperidone (BCS Class II drug). mmePEG(750)P(CL-co-TMC) was able to cross Caco-2 monolayer via a saturable transport mechanism. The oral bioavailability of the polymer was 40%. Polymeric micelles based on mmePEG(750)P(CL-co-TMC) showed very low clearance by the reticuloendothelial system (RES) and a renal excretion. A sustained release of risperidone was observed. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：47 / 55

页数：9

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