Perceiving the epigenetic landscape through histone readers

被引：603
作者：
Musselman, Catherine A. [1 ]
Lalonde, Marie-Eve [2 ]
Cote, Jacques [2 ]
Kutateladze, Tatiana G. [1 ]
机构：
[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA
[2] Univ Laval, Canc Res Ctr, Hotel Dieu Quebec, Quebec City, PQ, Canada
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 12期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
CHROMATIN-REMODELING COMPLEX; STATE-SPECIFIC RECOGNITION; METHYL-LYSINE-BINDING; DOUBLE-STRAND BREAKS; TANDEM PHD FINGER; STRUCTURAL BASIS; H3; TAIL; MOLECULAR-BASIS; DNA-REPLICATION; CODING REGIONS;
D O I：
10.1038/nsmb.2436
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for regulating chromatin structure and dynamics. PTMs can alter direct interactions between histones and DNA and serve as docking sites for protein effectors, or readers, of these PTMs. Binding of the readers recruits or stabilizes various components of the nuclear signaling machinery at specific genomic sites, mediating fundamental DNA-templated processes, including gene transcription and DNA recombination, replication and repair. In this review, we highlight the latest advances in characterizing histone-binding mechanisms and identifying new epigenetic readers and summarize the functional significance of PTM recognition.
引用
收藏
页码：1218 / 1227
页数：10
相关论文
共 151 条
  • [11] Methylation of histone H3 Lys 4 in coding regions of active genes
    Bernstein, BE
    Humphrey, EL
    Erlich, RL
    Schneider, R
    Bouman, P
    Liu, JS
    Kouzarides, T
    Schreiber, SL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) : 8695 - 8700
  • [12] Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
    Bian, Chuanbing
    Xu, Chao
    Ruan, Jianbin
    Lee, Kenneth K.
    Burke, Tara L.
    Tempel, Wolfram
    Barsyte, Dalia
    Li, Jing
    Wu, Minhao
    Zhou, Bo O.
    Fleharty, Brian E.
    Paulson, Ariel
    Allali-Hassani, Abdellah
    Zhou, Jin-Qiu
    Mer, Georges
    Grant, Patrick A.
    Workman, Jerry L.
    Zang, Jianye
    Min, Jinrong
    [J]. EMBO JOURNAL, 2011, 30 (14) : 2829 - 2842
  • [13] A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae
    Biswas, Debabrata
    Takahata, Shinya
    Xin, Hua
    Dutta-Biswas, Rinku
    Yu, Yaxin
    Formosat, Tim
    Stillman, David J.
    [J]. GENETICS, 2008, 178 (02) : 649 - 659
  • [14] Epigenetic virtues of chromodomains
    Blus, Bartlomiej J.
    Wiggins, Kimberly
    Khorasanizadeh, Sepideh
    [J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 46 (06) : 507 - 526
  • [15] Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails
    Bock, Ina
    Kudithipudi, Srikanth
    Tamas, Raluca
    Kungulovski, Goran
    Dhayalan, Arunkumar
    Jeltsch, Albert
    [J]. BMC BIOCHEMISTRY, 2011, 12
  • [16] Molecular Signals of Epigenetic States
    Bonasio, Roberto
    Tu, Shengjiang
    Reinberg, Danny
    [J]. SCIENCE, 2010, 330 (6004) : 612 - 616
  • [17] Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    Botuyan, Maria Victoria
    Lee, Joseph
    Ward, Irene M.
    Kim, Ja-Eun
    Thompson, James R.
    Chen, Junjie
    Mer, Georges
    [J]. CELL, 2006, 127 (07) : 1361 - 1373
  • [18] Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
    Brien, Gerard L.
    Gambero, Guillermo
    O'Connell, David J.
    Jerman, Emilia
    Turner, Siobhan A.
    Egan, Chris M.
    Dunne, Eiseart J.
    Jurgens, Maike C.
    Wynne, Kieran
    Piao, Lianhua
    Lohan, Amanda J.
    Ferguson, Neil
    Shi, Xiaobing
    Sinha, Krishna M.
    Loftus, Brendan J.
    Cagney, Gerard
    Bracken, Adrian P.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (12) : 1273 - +
  • [19] Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
    Brownell, JE
    Zhou, JX
    Ranalli, T
    Kobayashi, R
    Edmondson, DG
    Roth, SY
    Allis, CD
    [J]. CELL, 1996, 84 (06) : 843 - 851
  • [20] Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks
    Bua, Dennis J.
    Kuo, Alex J.
    Cheung, Peggie
    Liu, Chih Long
    Migliori, Valentina
    Espejo, Alexsandra
    Casadio, Fabio
    Bassi, Christian
    Amati, Bruno
    Bedford, Mark T.
    Guccione, Ernesto
    Gozani, Or
    [J]. PLOS ONE, 2009, 4 (08):
12345678910