Perceiving the epigenetic landscape through histone readers

被引：620

作者：

Musselman, Catherine A. ^{[1
]}

Lalonde, Marie-Eve ^{[2
]}

Cote, Jacques ^{[2
]}

Kutateladze, Tatiana G. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA

[2] Univ Laval, Canc Res Ctr, Hotel Dieu Quebec, Quebec City, PQ, Canada

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 12期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

CHROMATIN-REMODELING COMPLEX; STATE-SPECIFIC RECOGNITION; METHYL-LYSINE-BINDING; DOUBLE-STRAND BREAKS; TANDEM PHD FINGER; STRUCTURAL BASIS; H3; TAIL; MOLECULAR-BASIS; DNA-REPLICATION; CODING REGIONS;

D O I：

10.1038/nsmb.2436

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for regulating chromatin structure and dynamics. PTMs can alter direct interactions between histones and DNA and serve as docking sites for protein effectors, or readers, of these PTMs. Binding of the readers recruits or stabilizes various components of the nuclear signaling machinery at specific genomic sites, mediating fundamental DNA-templated processes, including gene transcription and DNA recombination, replication and repair. In this review, we highlight the latest advances in characterizing histone-binding mechanisms and identifying new epigenetic readers and summarize the functional significance of PTM recognition.

引用

页码：1218 / 1227

页数：10

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