Perceiving the epigenetic landscape through histone readers

被引：603
作者：
Musselman, Catherine A. [1 ]
Lalonde, Marie-Eve [2 ]
Cote, Jacques [2 ]
Kutateladze, Tatiana G. [1 ]
机构：
[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO USA
[2] Univ Laval, Canc Res Ctr, Hotel Dieu Quebec, Quebec City, PQ, Canada
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 12期
基金：
加拿大健康研究院; 美国国家卫生研究院;
关键词：
CHROMATIN-REMODELING COMPLEX; STATE-SPECIFIC RECOGNITION; METHYL-LYSINE-BINDING; DOUBLE-STRAND BREAKS; TANDEM PHD FINGER; STRUCTURAL BASIS; H3; TAIL; MOLECULAR-BASIS; DNA-REPLICATION; CODING REGIONS;
D O I：
10.1038/nsmb.2436
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for regulating chromatin structure and dynamics. PTMs can alter direct interactions between histones and DNA and serve as docking sites for protein effectors, or readers, of these PTMs. Binding of the readers recruits or stabilizes various components of the nuclear signaling machinery at specific genomic sites, mediating fundamental DNA-templated processes, including gene transcription and DNA recombination, replication and repair. In this review, we highlight the latest advances in characterizing histone-binding mechanisms and identifying new epigenetic readers and summarize the functional significance of PTM recognition.
引用
收藏
页码：1218 / 1227
页数：10
相关论文
共 151 条
  • [1] A Quantitative, High-Throughput Reverse Genetic Screen Reveals Novel Connections between Pre-mRNA Splicing and 5′ and 3′ End Transcript Determinants
    Albulescu, Laura-Oana
    Sabet, Nevin
    Gudipati, Mohanram
    Stepankiw, Nicholas
    Bergman, Zane J.
    Huffaker, Tim C.
    Pleiss, Jeffrey A.
    [J]. PLOS GENETICS, 2012, 8 (03):
  • [2] A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome
    Alekseyenko, Artyom A.
    Peng, Shouyong
    Larschan, Erica
    Gorchakov, Andrey A.
    Lee, Ok-Kyung
    Kharchenko, Peter
    McGrath, Sean D.
    Wang, Charlotte I.
    Mardis, Elaine R.
    Park, Peter J.
    Kuroda, Mitzi I.
    [J]. CELL, 2008, 134 (04) : 599 - 609
  • [3] ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS
    ALLFREY, VG
    FAULKNER, R
    MIRSKY, AE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) : 786 - +
  • [4] Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
    Arita, Kyohei
    Isogai, Shin
    Oda, Takashi
    Unoki, Motoko
    Sugita, Kazuya
    Sekiyama, Naotaka
    Kuwata, Keiko
    Hamamoto, Ryuji
    Tochio, Hidehito
    Sato, Mamoru
    Ariyoshi, Mariko
    Shirakawa, Masahiro
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) : 12950 - 12955
  • [5] The MYST family of histone acetyltransferases and their intimate links to cancer
    Avvakumov, N.
    Cote, J.
    [J]. ONCOGENE, 2007, 26 (37) : 5395 - 5407
  • [6] Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
    Ballare, Cecilia
    Lange, Martin
    Lapinaite, Audrone
    Martin, Gloria Mas
    Morey, Lluis
    Pascual, Gloria
    Liefke, Robert
    Simon, Bernd
    Shi, Yang
    Gozani, Or
    Carlomagno, Teresa
    Aznar Benitah, Salvador
    Di Croce, Luciano
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (12) : 1257 - +
  • [7] Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes
    Bannister, AJ
    Schneider, R
    Myers, FA
    Thorne, AW
    Crane-Robinson, C
    Kouzarides, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) : 17732 - 17736
  • [8] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [9] Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation
    Bartke, Till
    Vermeulen, Michiel
    Xhemalce, Blerta
    Robson, Samuel C.
    Mann, Matthias
    Kouzarides, Tony
    [J]. CELL, 2010, 143 (03) : 470 - 484
  • [10] An operational definition of epigenetics
    Berger, Shelley L.
    Kouzarides, Tony
    Shiekhattar, Ramin
    Shilatifard, Ali
    [J]. GENES & DEVELOPMENT, 2009, 23 (07) : 781 - 783
12345678910