Evolutionary and Ecological Characterization of Mayaro Virus Strains Isolated during an Outbreak, Venezuela, 2010

被引：98
作者：
Auguste, Albert J. [1 ]
Liria, Jonathan [2 ]
Forrester, Naomi L. [1 ]
Giambalvo, Dileyvic
Moncada, Maria
Long, Kanya C. [1 ]
Moron, Dulce
de Manzione, Nuns [3 ]
Tesh, Robert B. [1 ]
Halsey, Eric S. [4 ]
Kochel, Tadeusz J. [4 ]
Hernandez, Rosa
Navarro, Juan-Carlos [5 ]
Weaver, Scott C. [1 ]
机构：
[1] Univ Texas Med Branch, Galveston, TX 77555 USA
[2] Univ Carabobo, Naguanagua Valencia, Venezuela
[3] Ctr Invest Virosis Hemorrag & Enfermedades Transm, Guanare, Portuguesa Stat, Venezuela
[4] US Naval, Med Res Unit 6, Lima, Peru
[5] Cent Univ Venezuela, Caracas, Venezuela
来源：
EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 10期
基金：
美国国家卫生研究院;
关键词：
HUMAN-DISEASE AGENT; YELLOW-FEVER VIRUS; SOUTH-AMERICA; FRENCH-GUIANA; BRAZIL; TRANSMISSION; BELTERRA; TRINIDAD; EPIDEMIOLOGY; ARBOVIRUS;
D O I：
10.3201/eid2110.141660
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estacion village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing approximate to 17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged approximate to 150 years ago and genotype diverged N approximate to 250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.
引用
收藏
页码：1742 / 1750
页数：9
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