Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

被引：120
作者：
Barton, Anne [1 ]
Thomson, Wendy [1 ]
Ke, Xiayi [1 ]
Eyre, Steve [1 ]
Hinks, Anne [1 ]
Bowes, John [1 ]
Plant, Darren [1 ]
Gibbons, Laura J. [1 ]
Wilson, Anthony G. [2 ]
Bax, Deborah E. [2 ]
Morgan, Ann W. [3 ]
Emery, Paul [3 ]
Steer, Sophia [4 ]
Hocking, Lynne [5 ]
Reid, David M. [5 ]
Wordsworth, Paul [6 ]
Harrison, Pille [6 ]
Worthington, Jane [1 ]
机构：
[1] Univ Manchester, Arthritis Res Campaign Epidemiol Unit, Manchester, Lancs, England
[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2JF, S Yorkshire, England
[3] Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England
[4] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, London SE5 9RS, England
[5] Univ Aberdeen, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB25 2ZD, Scotland
[6] Univ Oxford, Inst Musculoskeletal Sci, Botnar Res Ctr, Oxford OX3 7LD, England
来源：
NATURE GENETICS | 2008年 / 40卷 / 10期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1038/ng.218
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
引用
收藏
页码：1156 / 1159
页数：4
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