Gender-specific reference intervals for cord blood leptin in Crete, Greece

被引：9
|
作者：
Karakosta, Polyxeni [1 ,2 ]
Georgiou, Vaggelis [2 ]
Fthenou, Eleni [2 ]
Margioris, Andrew [3 ]
Castanas, Elias [1 ]
Kogevinas, Manolis [4 ,5 ,6 ,7 ]
Kampa, Marilena [1 ]
Chatzi, Leda [2 ]
机构：
[1] Univ Crete, Dept Expt Endocrinol, Sch Med, Iraklion 71003, Greece
[2] Univ Crete, Dept Social Med, Sch Med, Iraklion 71003, Greece
[3] Univ Crete, Sch Med, Dept Clin Chem Biochem, Iraklion 71003, Crete, Greece
[4] Natl Sch Publ Hlth, Athens 11521, Greece
[5] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain
[6] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain
[7] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2012年 / 171卷 / 10期
关键词：
Leptin; Cord blood; Reference intervals; Gender; METABOLIC SYNDROME; BREAST-MILK; BIRTH; METAANALYSIS; ADIPONECTIN; HORMONES; CHILDREN; INFANTS; OBESITY; DISEASE;
D O I：
10.1007/s00431-012-1804-7
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Cord leptin is a biomarker of fetal growth and adiposity with a role in predicting weight gain during the first months of life and childhood obesity. Our objective was to calculate gender-specific reference intervals for cord blood leptin in healthy neonates in Crete, Greece. We used data from the prospective mother-child cohort ("Rhea" study) in Crete, Greece. The analysis included 398 neonates chosen with strict inclusion criteria based on maternal and fetal characteristics. Cord leptin reference intervals for male neonates were 1.4-18.2 ng/mL and for females 2.0-25.8 ng/mL. Females had higher leptin levels (median 7.4; IQR 4.7-10.9) compared to males (median 4.9; IQR 3.2-7.6) (p < 0.001). Conclusion Gender-specific reference ranges are essential in clinical practice for correct interpretation of leptin values in cord blood and early detection of childhood obesity.
引用
收藏
页码：1563 / 1566
页数：4
相关论文
共 50 条
  • [41] Trimester-specific reference intervals for blood lipid levels and their associations with adverse pregnancy outcomes in Southeast China
    Yang, Lili
    Liu, Zhaozhen
    Chen, Jiayi
    Miao, Chong
    Li, Qingxiu
    Chen, Jinying
    Liu, Wenjuan
    Gao, Haiyan
    Li, Wei
    Wu, Zhengqin
    Sun, Bin
    Zhu, Yibing
    Li, Haibo
    LIPIDS IN HEALTH AND DISEASE, 2025, 24 (01)
  • [42] Age- and gender-specific reference values for urine albumin/creatinine ratio in children of southwest China
    Wu, DaoQi
    Yang, HaiPing
    Luo, Juan
    Zhang, GaoFu
    Li, ShaoJun
    Wang, Mo
    Tang, XueHei
    Wang, Zhitie
    Xu, ZhenE
    Li, Qiu
    CLINICA CHIMICA ACTA, 2014, 431 : 239 - 243
  • [43] Establishment of Age- and Gender-Specific Reference Ranges for 36 Routine and 57 Cell Population Data Items in a New Automated Blood Cell Analyzer, Sysmex XN-2000
    Park, Sang Hyuk
    Park, Chan-Jeoung
    Lee, Bo-Ra
    Kim, Mi-Jeong
    Han, Min-Young
    Cho, Young-Uk
    Jang, Seongsoo
    ANNALS OF LABORATORY MEDICINE, 2016, 36 (03) : 244 - 249
  • [44] Cetirizine inhibits gender-specific blood cell dynamics upon allergen contact in allergic rhinitis
    Jordakieva, G.
    Kundi, M.
    Lemell, P.
    Zieglmayer, R.
    Zieglmayer, P.
    Jensen-Jarolim, E.
    Crevenna, R.
    CLINICAL IMMUNOLOGY, 2020, 215
  • [45] Gender-specific associations of sleep duration with uncontrolled blood pressure in middle-aged patients
    Zuo, Huijuan
    Wang, Jinwen
    Lin, Yun
    Deng, Liqun
    Su, Jianglian
    Zhang, Juan
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2016, 38 (02) : 125 - 130
  • [46] Age-specific and gender-specific radiation risks in paediatric angiography and interventional cardiology: conversion coefficients and risk reference values
    Karambatsakidou, Angeliki
    Steiner, Kristoffer
    Fransson, Annette
    Poludniowski, Gavin
    BRITISH JOURNAL OF RADIOLOGY, 2020, 93 (1110)
  • [47] Gender-Specific Blood Pressure and Heart Rate Differences in Adolescents Smoking Cigarettes, Waterpipes or Both
    Alomari, Mahmoud A.
    Al-Sheyab, Nihaya A.
    Mokdad, Ali H.
    SUBSTANCE USE & MISUSE, 2020, 55 (02) : 296 - 303
  • [48] Complete Blood Count Reference Values of Cord Blood in Taiwan and the Influence of Gender and Delivery Route on Them
    Chang, Yu-Hsun
    Yang, Shang-Hsien
    Wang, Tso-Fu
    Lin, Teng-Yi
    Yang, Kuo-Liang
    Chen, Shu-Huey
    PEDIATRICS AND NEONATOLOGY, 2011, 52 (03) : 155 - 160
  • [49] Determination of reference intervals for umbilical cord arterial and venous blood gas analysis of healthy Thoroughbred foals
    Jeawon, Sunita S.
    Katz, Lisa M.
    Galvin, Noreen P.
    Fogarty, Ursula M.
    Duggan, Vivienne E.
    THERIOGENOLOGY, 2018, 118 : 1 - 6
  • [50] Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
    Cacabelos, Daniel
    Ramirez-Nunez, Omar
    Belen Granado-Serrano, Ana
    Torres, Pascual
    Ayala, Victoria
    Moiseeva, Victoria
    Povedano, Monica
    Ferrer, Isidre
    Pamplona, Reinald
    Portero-Otin, Manuel
    Boada, Jordi
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2016, 4 : 3
12345