Gender-specific reference intervals for cord blood leptin in Crete, Greece

被引：9
|
作者：
Karakosta, Polyxeni [1 ,2 ]
Georgiou, Vaggelis [2 ]
Fthenou, Eleni [2 ]
Margioris, Andrew [3 ]
Castanas, Elias [1 ]
Kogevinas, Manolis [4 ,5 ,6 ,7 ]
Kampa, Marilena [1 ]
Chatzi, Leda [2 ]
机构：
[1] Univ Crete, Dept Expt Endocrinol, Sch Med, Iraklion 71003, Greece
[2] Univ Crete, Dept Social Med, Sch Med, Iraklion 71003, Greece
[3] Univ Crete, Sch Med, Dept Clin Chem Biochem, Iraklion 71003, Crete, Greece
[4] Natl Sch Publ Hlth, Athens 11521, Greece
[5] Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain
[6] Hosp del Mar, Res Inst, IMIM, Barcelona, Spain
[7] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2012年 / 171卷 / 10期
关键词：
Leptin; Cord blood; Reference intervals; Gender; METABOLIC SYNDROME; BREAST-MILK; BIRTH; METAANALYSIS; ADIPONECTIN; HORMONES; CHILDREN; INFANTS; OBESITY; DISEASE;
D O I：
10.1007/s00431-012-1804-7
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Cord leptin is a biomarker of fetal growth and adiposity with a role in predicting weight gain during the first months of life and childhood obesity. Our objective was to calculate gender-specific reference intervals for cord blood leptin in healthy neonates in Crete, Greece. We used data from the prospective mother-child cohort ("Rhea" study) in Crete, Greece. The analysis included 398 neonates chosen with strict inclusion criteria based on maternal and fetal characteristics. Cord leptin reference intervals for male neonates were 1.4-18.2 ng/mL and for females 2.0-25.8 ng/mL. Females had higher leptin levels (median 7.4; IQR 4.7-10.9) compared to males (median 4.9; IQR 3.2-7.6) (p < 0.001). Conclusion Gender-specific reference ranges are essential in clinical practice for correct interpretation of leptin values in cord blood and early detection of childhood obesity.
引用
收藏
页码：1563 / 1566
页数：4
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