Highly efficient phosphine-free Suzuki aryl couplings mediated by an in situ generated Pd(OAc)2/metformin complex in green media

被引：32
作者：
Alizadeh, A. [1 ,2 ]
Khodaei, M. M. [1 ,2 ]
Kordestani, D. [1 ]
Beygzadeh, M. [1 ]
机构：
[1] Razi Univ, Dept Chem, Kermanshah 67149, Iran
[2] Razi Univ, Nanosci & Nanotechnol Res Ctr, Kermanshah 67149, Iran
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 04期
关键词：
Suzuki-Miyaura coupling; Palladium; Biguanide; Catalysis; Organosuperbases; N-HETEROCYCLIC CARBENE; PALLADIUM NANOPARTICLES; AEROBIC CONDITIONS; CATALYST; LIGAND; CHLORIDES; WATER; HALIDES;
D O I：
10.1016/j.tetlet.2012.11.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An in situ generated complex of palladium(II) and a biguanide, namely metformin, was found to be a highly efficient homogeneous catalyst for the phosphine-free Suzuki-Miyaura reaction. Significant rate acceleration of the palladium-catalyzed coupling was observed when a 1:1 mixture of ethanol/water was employed as the reaction solvent. Using this protocol, a variety of aryl halides (Cl, Br, I) were subjected to reaction with various arylboronic acids and the products were obtained in good to excellent yields under mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：291 / 294
页数：4
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