Translating diagnostics and drug delivery technologies to low-resource settings

被引：13

作者：

Euliano, Erin M. ^{[1
]}

Sklavounos, Alexandros A. ^{[2
,3
]}

Wheeler, Aaron R. ^{[2
,3
,4
]}

McHugh, Kevin J. ^{[1
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[2] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

[3] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[4] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2022年 / 14卷 / 666期

基金：

美国国家卫生研究院;

关键词：

MENINGOCOCCAL CONJUGATE VACCINE; AFRICAN MENINGITIS BELT; OF-CARE DIAGNOSTICS; AMPHOTERICIN-B; IMMUNOLOGICAL PARALYSIS; MICRONEEDLE PATCHES; CHOLESTERYL SULFATE; INFECTIOUS-DISEASES; INTRAVAGINAL RING; CONTRACEPTIVE USE;

D O I：

10.1126/scitranslmed.abm1732

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Diagnostics and drug delivery technologies engineered for low-resource settings aim to meet their technical design specifications using strategies that are compatible with limited equipment, infrastructure, and operator training. Despite many preclinical successes, very few of these devices have been translated to the clinic. Here, we identify factors that contribute to the clinical success of diagnostics and drug delivery systems for low-resource settings, including the need to engage key stakeholders at an early stage, and provide recommendations for the clinical translation of future medical technologies.

引用

页数：17

共 20 条

[1] Point-of-Care Diagnostics in Low-Resource Settings and Their Impact on Care in the Age of the Noncommunicable and Chronic Disease Epidemic
Weigl, Bernhard H.
Neogi, Tina
McGuire, Helen
JALA, 2014, 19 (03): : 248 - 257
[2] A Review of Antimicrobial Resistance in Poultry Farming within Low-Resource Settings
Hedman, Hayden D.
Vasco, Karla A.
Zhang, Lixin
ANIMALS, 2020, 10 (08): : 1 - 39
[3] The Promise of Clinical Decision Support Systems Targetting Low-Resource Settings
Kiyasseh, Dani
Zhu, Tingting
Clifton, David
IEEE REVIEWS IN BIOMEDICAL ENGINEERING, 2022, 15 : 354 - 371
[4] An Automated Versatile Diagnostic Workflow for Infectious Disease Detection in Low-Resource Settings
Urrutia Iturritza, Miren
Mlotshwa, Phuthumani
Gantelius, Jesper
Alfven, Tobias
Loh, Edmund
Karlsson, Jens
Hadjineophytou, Chris
Langer, Krzysztof
Mitsakakis, Konstantinos
Russom, Aman
Joensson, Hakan N.
Gaudenzi, Giulia
MICROMACHINES, 2024, 15 (06)
[5] Emerging technologies in point-of-care molecular diagnostics for resource-limited settings
Peeling, Rosanna W.
McNerney, Ruth
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2014, 14 (05) : 525 - 534
[6] Non-inferiority designs comparing placebo to a proven therapy for childhood pneumonia in low-resource settings
May, Susanne
Brown, Siobhan P.
Schmicker, Robert H.
Emerson, Scott S.
Nkwopara, Evangelyn
Ginsburg, Amy Sarah
CLINICAL TRIALS, 2020, 17 (02) : 129 - 137
[7] Global Women's Health Is More Than Maternal Health: A Review of Gynecology Care Needs in Low-Resource Settings
Robinson, Nuriya
Stoffel, Cynthia
Haider, Sadia
OBSTETRICAL & GYNECOLOGICAL SURVEY, 2015, 70 (03) : 211 - 222
[8] Antiretroviral treatment in low-resource settings: what has changed in the last 10 years and what needs to change in the coming years?
Mehta, Mandana
Semitala, Fred
Lynen, Lutgarde
Colebunders, Robert
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2012, 10 (11) : 1287 - 1296
[9] Strategies for overcoming challenges for decentralised diagnostics in resource-limited and catastrophe settings
Sharma, Shikha
Crawley, Aoife
O'Kennedy, Richard
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2017, 17 (02) : 109 - 118
[10] Facilitators and barriers to in vitro diagnostics implementation in resource-limited settings: A scoping review
Ansu-Mensah, Monica
Kuupiel, Desmond
Asiamah, Emmanuel A.
Ginindza, Themba G.
AFRICAN JOURNAL OF PRIMARY HEALTH CARE & FAMILY MEDICINE, 2023, 15 (01)

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