Significance of taurine transporter (TauT) in homeostasis and its layers of regulation

被引：51

作者：

Baliou, Stella ^{[1
]}

Kyriakopoulos, Anthony M. ^{[2
]}

Goulielmaki, Maria ^{[1
]}

Panayiotidis, Michalis I. ^{[3
,4
]}

Spandidos, Demetrios A. ^{[5
]}

Zoumpourlis, Vassilios ^{[1
]}

机构：

[1] Natl Hellen Res Fdn, 48 Vas Konstantinou Av, Athens 11635, Greece

[2] Nasco AD Biotechnol Lab, Piraeus 18536, Greece

[3] Cyprus Inst Neurol & Genet, Dept Electron Microscopy & Mol Pathol, CY-2371 Nicosia, Cyprus

[4] Cyprus Sch Mol Med, CY-1683 Nicosia, Cyprus

[5] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71003, Greece

来源：

MOLECULAR MEDICINE REPORTS | 2020年 / 22卷 / 03期

关键词：

taurine transporter; regulation; taurine deficient conditions; ORGANIC OSMOLYTE TAURINE; BLOOD-BRAIN-BARRIER; SULFINIC ACID DECARBOXYLASE; BRUSH-BORDER MEMBRANE; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; CYSTEINE METABOLISM; ADAPTIVE REGULATION; NONHEPATIC TISSUES; MOLECULAR-CLONING;

D O I：

10.3892/mmr.2020.11321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Taurine (2-aminoethanesulfonic acid) contributes to homeostasis, mainly through its antioxidant and osmoregulatory properties. Taurine's influx and efflux are mainly mediated through the ubiquitous expression of the sodium/chloride-dependent taurine transporter, located on the plasma membrane. The significance of the taurine transporter has been shown in various organ malfunctions in taurine-transporter-null mice. The taurine transporter differentially responds to various cellular stimuli including ionic environment, electrochemical charge, and pH changes. The renal system has been used as a model to evaluate the factors that significantly determine the regulation of taurine transporter regulation.

引用

页码：2163 / 2173

页数：11

共 128 条

[11] Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar)
Espe, Marit
Holen, Elisabeth
[J]. BRITISH JOURNAL OF NUTRITION, 2013, 110 (01) : 20 - 28
[12] FALANY CN, 1994, J BIOL CHEM, V269, P19375
[13] The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity
Franchi-Gazzola, R
Gaccioli, F
Bevilacqua, E
Visigalli, R
Dall'Asta, V
Sala, R
Varoqui, H
Erickson, JD
Gazzola, GC
Bussolati, O
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2004, 1667 (02): : 157 - 166
[14] Diabetic retinopathy
Frank, RN
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (01) : 48 - 58
[15] URINARY TAURINE EXCRETION AS A FUNCTION OF TAURINE INTAKE IN ADULT CATS
GLASS, EN
ODLE, J
BAKER, DH
[J]. JOURNAL OF NUTRITION, 1992, 122 (05) : 1135 - 1142
[16] Age-related changes of muscle and plasma amino acids in healthy children
Hammarqvist, Folke
Angsten, Gertrud
Meurling, Staffan
Andersson, Kerstin
Wernerman, Jan
[J]. AMINO ACIDS, 2010, 39 (02) : 359 - 366
[17] The taurine transporter: mechanisms of regulation
Han, X.
Patters, A. B.
Jones, D. P.
Zelikovic, I.
Chesney, R. W.
[J]. ACTA PHYSIOLOGICA, 2006, 187 (1-2) : 61 - 73
[18] The taurine transporter gene and its role in renal development
Han, X
Budreau, AM
Chesney, RW
[J]. AMINO ACIDS, 2000, 19 (3-4) : 499 - 507
[19] Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells
Han, XB
Patters, AB
Chesney, RW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) : 39266 - 39273
[20] Han XB, 2000, ADV EXP MED BIOL, V483, P535

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