Significance of taurine transporter (TauT) in homeostasis and its layers of regulation

被引：60

作者：

Baliou, Stella ^{[1
]}

Kyriakopoulos, Anthony M. ^{[2
]}

Goulielmaki, Maria ^{[1
]}

Panayiotidis, Michalis I. ^{[3
,4
]}

Spandidos, Demetrios A. ^{[5
]}

Zoumpourlis, Vassilios ^{[1
]}

机构：

[1] Natl Hellen Res Fdn, 48 Vas Konstantinou Av, Athens 11635, Greece

[2] Nasco AD Biotechnol Lab, Piraeus 18536, Greece

[3] Cyprus Inst Neurol & Genet, Dept Electron Microscopy & Mol Pathol, CY-2371 Nicosia, Cyprus

[4] Cyprus Sch Mol Med, CY-1683 Nicosia, Cyprus

[5] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71003, Greece

来源：

MOLECULAR MEDICINE REPORTS | 2020年 / 22卷 / 03期

关键词：

taurine transporter; regulation; taurine deficient conditions; ORGANIC OSMOLYTE TAURINE; BLOOD-BRAIN-BARRIER; SULFINIC ACID DECARBOXYLASE; BRUSH-BORDER MEMBRANE; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; CYSTEINE METABOLISM; ADAPTIVE REGULATION; NONHEPATIC TISSUES; MOLECULAR-CLONING;

D O I：

10.3892/mmr.2020.11321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Taurine (2-aminoethanesulfonic acid) contributes to homeostasis, mainly through its antioxidant and osmoregulatory properties. Taurine's influx and efflux are mainly mediated through the ubiquitous expression of the sodium/chloride-dependent taurine transporter, located on the plasma membrane. The significance of the taurine transporter has been shown in various organ malfunctions in taurine-transporter-null mice. The taurine transporter differentially responds to various cellular stimuli including ionic environment, electrochemical charge, and pH changes. The renal system has been used as a model to evaluate the factors that significantly determine the regulation of taurine transporter regulation.

引用

页码：2163 / 2173

页数：11

共 128 条

[11] Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar) [J].

Espe, Marit ;

Holen, Elisabeth .

BRITISH JOURNAL OF NUTRITION, 2013, 110 (01) :20-28

[12]

FALANY CN, 1994, J BIOL CHEM, V269, P19375

[13] The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity [J].

Franchi-Gazzola, R ;

Gaccioli, F ;

Bevilacqua, E ;

Visigalli, R ;

Dall'Asta, V ;

Sala, R ;

Varoqui, H ;

Erickson, JD ;

Gazzola, GC ;

Bussolati, O .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2004, 1667 (02) :157-166

[14] Diabetic retinopathy [J].

Frank, RN .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (01) :48-58

[15] URINARY TAURINE EXCRETION AS A FUNCTION OF TAURINE INTAKE IN ADULT CATS [J].

GLASS, EN ;

ODLE, J ;

BAKER, DH .

JOURNAL OF NUTRITION, 1992, 122 (05) :1135-1142

[16] Age-related changes of muscle and plasma amino acids in healthy children [J].

Hammarqvist, Folke ;

Angsten, Gertrud ;

Meurling, Staffan ;

Andersson, Kerstin ;

Wernerman, Jan .

AMINO ACIDS, 2010, 39 (02) :359-366

[17] The taurine transporter: mechanisms of regulation [J].

Han, X. ;

Patters, A. B. ;

Jones, D. P. ;

Zelikovic, I. ;

Chesney, R. W. .

ACTA PHYSIOLOGICA, 2006, 187 (1-2) :61-73

[18] The taurine transporter gene and its role in renal development [J].

Han, X ;

Budreau, AM ;

Chesney, RW .

AMINO ACIDS, 2000, 19 (3-4) :499-507

[19] Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells [J].

Han, XB ;

Patters, AB ;

Chesney, RW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39266-39273

[20]

Han XB, 2000, ADV EXP MED BIOL, V483, P535

← 1 2 3 4 5 6 7 8 9 10 →