Significance of taurine transporter (TauT) in homeostasis and its layers of regulation

被引：55

作者：

Baliou, Stella ^{[1
]}

Kyriakopoulos, Anthony M. ^{[2
]}

Goulielmaki, Maria ^{[1
]}

Panayiotidis, Michalis I. ^{[3
,4
]}

Spandidos, Demetrios A. ^{[5
]}

Zoumpourlis, Vassilios ^{[1
]}

机构：

[1] Natl Hellen Res Fdn, 48 Vas Konstantinou Av, Athens 11635, Greece

[2] Nasco AD Biotechnol Lab, Piraeus 18536, Greece

[3] Cyprus Inst Neurol & Genet, Dept Electron Microscopy & Mol Pathol, CY-2371 Nicosia, Cyprus

[4] Cyprus Sch Mol Med, CY-1683 Nicosia, Cyprus

[5] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71003, Greece

来源：

MOLECULAR MEDICINE REPORTS | 2020年 / 22卷 / 03期

关键词：

taurine transporter; regulation; taurine deficient conditions; ORGANIC OSMOLYTE TAURINE; BLOOD-BRAIN-BARRIER; SULFINIC ACID DECARBOXYLASE; BRUSH-BORDER MEMBRANE; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; CYSTEINE METABOLISM; ADAPTIVE REGULATION; NONHEPATIC TISSUES; MOLECULAR-CLONING;

D O I：

10.3892/mmr.2020.11321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Taurine (2-aminoethanesulfonic acid) contributes to homeostasis, mainly through its antioxidant and osmoregulatory properties. Taurine's influx and efflux are mainly mediated through the ubiquitous expression of the sodium/chloride-dependent taurine transporter, located on the plasma membrane. The significance of the taurine transporter has been shown in various organ malfunctions in taurine-transporter-null mice. The taurine transporter differentially responds to various cellular stimuli including ionic environment, electrochemical charge, and pH changes. The renal system has been used as a model to evaluate the factors that significantly determine the regulation of taurine transporter regulation.

引用

页码：2163 / 2173

页数：11

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