Significance of taurine transporter (TauT) in homeostasis and its layers of regulation

被引：51
作者：
Baliou, Stella [1 ]
Kyriakopoulos, Anthony M. [2 ]
Goulielmaki, Maria [1 ]
Panayiotidis, Michalis I. [3 ,4 ]
Spandidos, Demetrios A. [5 ]
Zoumpourlis, Vassilios [1 ]
机构：
[1] Natl Hellen Res Fdn, 48 Vas Konstantinou Av, Athens 11635, Greece
[2] Nasco AD Biotechnol Lab, Piraeus 18536, Greece
[3] Cyprus Inst Neurol & Genet, Dept Electron Microscopy & Mol Pathol, CY-2371 Nicosia, Cyprus
[4] Cyprus Sch Mol Med, CY-1683 Nicosia, Cyprus
[5] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71003, Greece
来源：
MOLECULAR MEDICINE REPORTS | 2020年 / 22卷 / 03期
关键词：
taurine transporter; regulation; taurine deficient conditions; ORGANIC OSMOLYTE TAURINE; BLOOD-BRAIN-BARRIER; SULFINIC ACID DECARBOXYLASE; BRUSH-BORDER MEMBRANE; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATION; CYSTEINE METABOLISM; ADAPTIVE REGULATION; NONHEPATIC TISSUES; MOLECULAR-CLONING;
D O I：
10.3892/mmr.2020.11321
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Taurine (2-aminoethanesulfonic acid) contributes to homeostasis, mainly through its antioxidant and osmoregulatory properties. Taurine's influx and efflux are mainly mediated through the ubiquitous expression of the sodium/chloride-dependent taurine transporter, located on the plasma membrane. The significance of the taurine transporter has been shown in various organ malfunctions in taurine-transporter-null mice. The taurine transporter differentially responds to various cellular stimuli including ionic environment, electrochemical charge, and pH changes. The renal system has been used as a model to evaluate the factors that significantly determine the regulation of taurine transporter regulation.
引用
收藏
页码：2163 / 2173
页数：11
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