Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases

被引：39

作者：

Hakiki, Bahia ^{[1
]}

Portaccio, Emilio ^{[1
]}

Giannini, Marta ^{[1
]}

Razzolini, Lorenzo ^{[1
]}

Pasto, Luisa ^{[1
]}

Amato, Maria Pia ^{[1
]}

机构：

[1] Univ Florence, Dept Neurol, I-50134 Florence, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2012年 / 18卷 / 11期

关键词：

Multiple sclerosis; fingolimod; rebound; DISEASE-ACTIVITY;

D O I：

10.1177/1352458512454773

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The objective of this article is to report our experience on fingolimod suspension in multiple sclerosis patients. We evaluated clinical and magnetic resonance (MR) outcomes in six patients after fingolimod discontinuation. Within three months from fingolimod suspension, five subjects returned to pre-treatment disease activity; one patient, however, exhibited a clear rebound of clinical and MR activity. Our findings suggest that clinical and MR outcomes after fingolimod suspension can vary among patients. Systematic collection of clinical, laboratory and imaging data is highly advisable to identify subjects who are at higher risk of rebound and to define effective management strategies in these subjects.

引用

页码：1636 / 1639

页数：4

共 8 条

[1] Mechanisms of Fingolimod's Efficacy and Adverse Effects in Multiple Sclerosis [J].