Facile one-pot green synthesis of tetrahydrobiphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation

被引：12
作者：
Shabalala, Nhlanhla Gracious [1 ]
Maddila, Suresh [1 ]
Jonnalagadda, Sreekantha B. [1 ]
机构：
[1] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills, ZA-4000 Durban, South Africa
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Green synthesis; One-pot synthesis; 2-Amino-1,3-dicarbonitriles; Functionalized aromatics; Multicomponent reactions; Ultrasound irradiation; MULTICOMPONENT SYNTHESIS; RECYCLABLE CATALYST; EFFICIENT SYNTHESIS; RAPID PROTOCOL; DERIVATIVES; CHEMISTRY; SONOCHEMISTRY; PYRIDINES; WATER;
D O I：
10.1007/s11164-016-2581-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and rapid procedure for the synthesis of 16 novel tetrahydrobiphenylene-1,3-dicarbonitrile derivatives (4a-p) is described, employing the reaction of aromatic aldehydes, malononitrile and 3-methyl-cyclohexanone or 2-methyl-cyclohexanone at room temperature in aqueous NaOH under ultrasonic irradiation, with excellent yields. The other attractive features of this protocol over conventional methods are the green principles, operational simplicity, easy handling, time-reducing, mild reaction conditions and no by-product production. [GRAPHICS] .
引用
收藏
页码：8097 / 8108
页数：12
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