Cyclic HIV protease inhibitors: Nonsymmetric cyclic ureas with excellent oral bioavailability and low drug resistance profiles.

被引：0

|

作者：

Lam, PYS ^{[1
]}

Rodgers, JD ^{[1
]}

Li, R ^{[1
]}

Ru, Y ^{[1
]}

Jadhav, PK ^{[1
]}

Chang, CH ^{[1
]}

Clark, CG ^{[1
]}

Seitz, SP ^{[1
]}

Bacheler, LT ^{[1
]}

Lam, GN ^{[1
]}

EricksonViitanen, S ^{[1
]}

Trainor, GL ^{[1
]}

Anderson, PS ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,WILMINGTON,DE 19880

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 213卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

收藏

页码：278 / MEDI

页数：1

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[32] Improved cyclic urea inhibitors of the HIV-I protease: Synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
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[33] Counteracting HIV-1 protease drug resistance: Structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities
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[34] HOT PAPERS - DRUG DESIGN - RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS BY LAM,P.Y.S., JADHAV,P.K., EYERMANN,C.J., HODGE,C.N., RU,Y., BACHELER,L.T., MEEK,J.L., OTTO,M.J., RAYNER,M.M., WONG,Y.N., CHANG,C.H., WEBER,P.C., JACKSON,D.A., SHARPE,T.R., ERICKSONVIITANEN,S.
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