Cyclic HIV protease inhibitors: Nonsymmetric cyclic ureas with excellent oral bioavailability and low drug resistance profiles.

被引：0

作者：

Lam, PYS ^{[1
]}

Rodgers, JD ^{[1
]}

Li, R ^{[1
]}

Ru, Y ^{[1
]}

Jadhav, PK ^{[1
]}

Chang, CH ^{[1
]}

Clark, CG ^{[1
]}

Seitz, SP ^{[1
]}

Bacheler, LT ^{[1
]}

Lam, GN ^{[1
]}

EricksonViitanen, S ^{[1
]}

Trainor, GL ^{[1
]}

Anderson, PS ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,WILMINGTON,DE 19880

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 213卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：278 / MEDI

页数：1

共 34 条

[1] Molecular recognition of cyclic HIV protease inhibitors: Nonsymmetric cyclic ureas with excellent oral bioavailability and low drug resistance profiles.
Lam, PYS
Rodgers, JD
Li, R
Ru, Y
Jadhav, PK
Chang, CH
Clark, CG
Seitz, SP
Ko, SS
Bacheler, LT
Klabe, RM
Lam, GN
Wright, MR
Erickson-Viitanen, S
Trainor, GL
Anderson, PS
FASEB JOURNAL, 1997, 11 (09): : A838 - A838
[2] A practical synthesis of nonpeptide cyclic ureas as potent HIV protease inhibitors
Rossano, L. T.
Lo, Y. S.
Anzalone, L.
Lee, Y.-C.
Tetrahedron Letters, 36 (28):
[3] A PRACTICAL SYNTHESIS OF NONPEPTIDE CYCLIC UREAS AS POTENT HIV PROTEASE INHIBITORS
ROSSANO, LT
LO, YS
ANZALONE, L
LEE, YC
MELONI, DJ
MOORE, JR
GALE, TM
ARNETT, JF
TETRAHEDRON LETTERS, 1995, 36 (28) : 4967 - 4970
[4] A PHARMACOKINETIC EVALUATION OF HIV PROTEASE INHIBITORS, CYCLIC UREAS, IN RATS AND DOGS
WONG, YN
BURCHAM, DL
SAXTON, PL
ERICKSONVIITANEN, S
GRUBB, MF
QUON, CY
HUANG, SM
BIOPHARMACEUTICS & DRUG DISPOSITION, 1994, 15 (07) : 535 - 544
[5] Heteroarylmethyl carboxamidobenzyl substituted cyclic ureas as HIV protease inhibitors.
Sherk, SR
Selby, TP
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 279 - MEDI
[6] RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
LAM, PYS
JADHAV, PK
EYERMANN, CJ
HODGE, CN
RU, Y
BACHELER, LT
MEEK, JL
OTTO, MJ
RAYNER, MM
WONG, YN
CHANG, CH
WEBER, PC
JACKSON, DA
SHARPE, TR
ERICKSONVIITANEN, S
SCIENCE, 1994, 263 (5145) : 380 - 384
[7] RATIONAL DESIGN OF POTENT, BIOAVAILABLE NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
ERICKSONVIITANEN, S
LAM, PYS
JADHAV, PK
EYERMANN, CJ
HODGE, CN
RU, Y
BACHELER, LT
MEEK, JL
OTTO, MJ
RAYNER, MM
WONG, YN
CHANG, CH
WEBER, PC
JACKSON, DA
SHARPE, TR
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 167 - 167
[8] CoMFA and CoMSIA studies on cyclic ureas as HIV-1 protease inhibitors.
Wang, X
Welsh, WJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U607 - U607
[9] DE-NOVO DESIGN OF POTENT NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
LAM, PYS
EYERMANN, CJ
JADHAV, PK
HODGE, CN
RU, Y
BACHELER, LT
MEEK, JL
OTTO, MJ
RAYNER, MM
WONG, NY
CHANG, CH
WEBER, PC
JACKSON, DA
SHARPE, TR
ERICKSONVIITANEN, SK
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 88 - COMP
[10] NOVEL AZA-CYCLIC UREAS THAT ARE POTENT INHIBITORS OF HIV PROTEASE .2.
STEWART, KD
PARK, CH
KONG, XP
SHAM, HL
ZHAO, C
HERRIN, T
BETEBENNER, DA
ROSENBROOK, W
MADIGAN, D
LIN, SQ
SALDIVAR, A
WIDEBURG, NE
KEMPF, DJ
NORBECK, DW
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 8 - MEDI

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