TERT-CLPTM1L Polymorphism rs401681 Contributes to Cancers Risk: Evidence from a Meta-Analysis Based on 29 Publications

被引:18
作者
Yin, Jieyun [1 ,2 ]
Li, Yangkai [3 ]
Yin, Ming [4 ]
Sun, Jingwen [1 ,2 ]
Liu, Li [1 ,2 ]
Qin, Qin [1 ,2 ]
Li, Xiaorong [1 ,2 ]
Long, Lu [1 ,2 ]
Nie, Shaofa [1 ,2 ]
Wei, Sheng [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, MOE Key Lab Environm & Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China
[3] Huazhong Univ Sci & Technol, Dept Thorac Surg, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China
[4] Geisinger Med Ctr, Dept Internal Med, Danville, PA 17822 USA
来源
PLOS ONE | 2012年 / 7卷 / 11期
基金
中国国家自然科学基金;
关键词
GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; MEAN TELOMERE LENGTH; LUNG-CANCER; SUSCEPTIBILITY LOCI; GENETIC-VARIATIONS; BREAST-CANCER; VARIANTS; TERT; PREDISPOSITION;
D O I
10.1371/journal.pone.0050650
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Some common genetic variants of TERT-CLPTM1L gene, which encode key protein subunits of telomerase, have been suggested to play a crucial role in tumorigenesis. The TERT-CLPTM1L polymorphism rs401681 was of special interest for cancers risk but with inconclusive results. Methodology/Principal Findings: We performed a comprehensive meta-analysis of 29 publications with a total of 91263 cases and 735952 controls. We assessed the strength of the association between rs401681 and overall cancers risk and performed subgroup analyses by cancer type, ethnicity, source of control, sample size and expected power. Rs401681 C allele was found to be associated with marginally increased cancers risk, with per allele OR of 1.04 (95%CI = 1.00-1.08, P-heterogeneity<0.001) and an expected power of 1.000. Following further stratified analyses, the increased cancers risk were discovered in subgroups of lung, bladder, prostate, basal cell carcinomas and Asians, while a declined risk of pancreatic cancer and melanoma were detected. Conclusions/Significance: These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
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页数:10
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