CANCER METABOLISM Tumour friend or foe

被引：35
作者：
Svensson, Robert U. [1 ]
Shaw, Reuben J. [1 ]
机构：
[1] Salk Inst Biol Studies, Howard Hughes Med Inst, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
来源：
NATURE | 2012年 / 485卷 / 7400期
关键词：
ACTIVATED PROTEIN-KINASE; AMPK; LKB1; PHOSPHORYLATION; DEPENDENCE; GROWTH;
D O I：
10.1038/485590a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Elucidation of a signalling pathway that promotes tumour-cell survival during metabolic stress reveals that a protein called AMPK may both hinder and enhance cancer progression. See Letter p.661
引用
收藏
页码：590 / 591
页数：2
相关论文
共 17 条
  • [1] Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    Bardeesy, N
    Sinha, M
    Hezel, AF
    Signoretti, S
    Hathaway, NA
    Sharpless, NE
    Loda, M
    Carrasco, DR
    DePinho, RA
    [J]. NATURE, 2002, 419 (6903) : 162 - 167
  • [2] The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
    Buzzai, M
    Bauer, DE
    Jones, RG
    DeBerardinis, RJ
    Hatzivassiliou, G
    Elstrom, RL
    Thompson, CB
    [J]. ONCOGENE, 2005, 24 (26) : 4165 - 4173
  • [3] PURIFICATION AND CHARACTERIZATION OF THE AMP-ACTIVATED PROTEIN-KINASE - COPURIFICATION OF ACETYL-COA CARBOXYLASE KINASE AND 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE KINASE-ACTIVITIES
    CARLING, D
    CLARKE, PR
    ZAMMIT, VA
    HARDIE, DG
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 186 (1-2): : 129 - 136
  • [4] Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
    Egan, Daniel F.
    Shackelford, David B.
    Mihaylova, Maria M.
    Gelino, Sara
    Kohnz, Rebecca A.
    Mair, William
    Vasquez, Debbie S.
    Joshi, Aashish
    Gwinn, Dana M.
    Taylor, Rebecca
    Asara, John M.
    Fitzpatrick, James
    Dillin, Andrew
    Viollet, Benoit
    Kundu, Mondira
    Hansen, Malene
    Shaw, Reuben J.
    [J]. SCIENCE, 2011, 331 (6016) : 456 - 461
  • [5] AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Gwinn, Dana M.
    Shackelford, David B.
    Egan, Daniel F.
    Mihaylova, Maria M.
    Mery, Annabelle
    Vasquez, Debbie S.
    Turk, Benjamin E.
    Shaw, Reuben J.
    [J]. MOLECULAR CELL, 2008, 30 (02) : 214 - 226
  • [6] Hallmarks of Cancer: The Next Generation
    Hanahan, Douglas
    Weinberg, Robert A.
    [J]. CELL, 2011, 144 (05) : 646 - 674
  • [7] AMPK: a nutrient and energy sensor that maintains energy homeostasis
    Hardie, D. Grahame
    Ross, Fiona A.
    Hawley, Simon A.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (04) : 251 - 262
  • [8] AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    Jeon, Sang-Min
    Chandel, Navdeep S.
    Hay, Nissim
    [J]. NATURE, 2012, 485 (7400) : 661 - +
  • [9] LKB1 modulates lung cancer differentiation and metastasis
    Ji, Hongbin
    Ramsey, Matthew R.
    Hayes, D. Neil
    Fan, Cheng
    McNamara, Kate
    Kozlowski, Piotr
    Torrice, Chad
    Wu, Michael C.
    Shimamura, Takeshi
    Perera, Samanthi A.
    Liang, Mei-Chih
    Cai, Dongpo
    Naumov, George N.
    Bao, Lei
    Contreras, Cristina M.
    Li, Danan
    Chen, Liang
    Krishnamurthy, Janakiraman
    Koivunen, Jussi
    Chirieac, Lucian R.
    Padera, Robert F.
    Bronson, Roderick T.
    Lindeman, Neal I.
    Christiani, David C.
    Lin, Xihong
    Shapiro, Geoffrey I.
    Jaenne, Pasi A.
    Johnson, Bruce E.
    Meyerson, Matthew
    Kwiatkowski, David J.
    Castrillon, Diego H.
    Bardeesy, Nabeel
    Sharpless, Norman E.
    Wong, Kwok-Kin
    [J]. NATURE, 2007, 448 (7155) : 807 - U7
  • [10] 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    Laderoute, Keith R.
    Amin, Khalid
    Calaoagan, Joy M.
    Knapp, Merrill
    Le, Theresamai
    Orduna, Juan
    Foretz, Marc
    Viollet, Benoit
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (14) : 5336 - 5347
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