Liver Retransplantation in HIV-Infected Patients: A Prospective Cohort Study

被引：8

作者：

Gastaca, M. ^{[2
]}

Aguero, F. ^{[3
]}

Rimola, A. ^{[1
,4
]}

Montejo, M. ^{[2
]}

Miralles, P. ^{[5
]}

Lozano, R. ^{[6
]}

Castells, L. ^{[4
,7
]}

Abradelo, M. ^{[8
]}

de la Mata, M. ^{[4
]}

San Juan Rodriguez, F. ^{[9
]}

Cordero, E. ^{[10
]}

del Campo, S. ^{[11
]}

Manzardo, C. ^{[1
]}

de Urbina, J. O. ^{[2
]}

Perez, I. ^{[1
]}

de la Rosa, G. ^{[12
]}

Miro, J. M. ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain

[2] Univ Basque Country, Hosp Univ Cruces, Bilbao, Spain

[3] Training Unit Prevent Med & Publ Hlth, Barcelona, Spain

[4] CIBEREHD, Madrid, Spain

[5] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[6] Hos Clin Univ Lozano Blesa, Zaragoza, Spain

[7] Univ Autonoma Barcelona, Hosp Vall dHebron, E-08193 Barcelona, Spain

[8] Hosp Univ Doce de Octubre, Madrid, Spain

[9] Hosp Univ La Fe, Valencia, Spain

[10] Hosp Univ Virgen del Rocio, Seville, Spain

[11] Hosp Univ Ramon & Cajal IRYCIS, Madrid, Spain

[12] ONT, Madrid, Spain

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 09期

关键词：

Chronic rejection; HBV infection; HCV infection; HCV recurrence; HIV infection; liver retransplantation; primary-graft nonfunction; Spain; survival; vascular thrombosis; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C; TRANSPLANT RECIPIENTS; COINFECTED PATIENTS; SURVIVAL; RECURRENCE; FAILURE; HCV;

D O I：

10.1111/j.1600-6143.2012.04142.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Information regarding liver retransplantation in HIV-infected patients is scant. Data from 14 HIV-infected patients retransplanted between 2002 and 2011 in Spain (6% retransplantation rate) were analyzed and compared with those from 157 matched HIV-negative retransplanted patients. In HIV-infected patients, early (=30 days) retransplantation was more frequently indicated (57% vs. 29%; p = 0.057), and retransplantation for HCV recurrence was less frequently indicated (7% vs. 37%; p = 0.036). Survival probability after retransplantation in HIV-positive patients was lower than in HIV-negative patients, 42% versus 64% at 3 years, although not significantly (p = 0.160). Among HIV-infected patients, those with undetectable HCV RNA at retransplantation and those with late (>30 days) retransplantation showed better 3-year survival probability (80% and 67%, respectively), similar to that in their respective HIV-negative counterparts (72% and 70%). In HIV-infected and HIV-negative patients, 3-year survival probability in those with positive HCV RNA at retransplantation was 22% versus 65% (p = 0.008); in those with early retransplantation, 3-year survival probability was 25% versus 56% (p = 0.282). HIV infection was controlled with antiretroviral therapy after retransplantation. In conclusion, HIV-infected patients taken as a whole have unsatisfactory survival after liver retransplantation, although patients with undetectable HCV RNA at retransplantation or undergoing late retransplantation show a more favorable outcome.

引用

页码：2465 / 2476

页数：12

共 31 条

[1]

[Anonymous], 2009 ANN REP US SCI

[2] Infectious disease assessment in solid organ transplant candidates [J].