Efficient Entry to the Pyrroloquinoline Core of Martinella Alkaloids via Novel Base-catalyzed Mukaiyama-Mannich Reaction

被引：9

作者：

Ikeda, Shuhei ^{[1
]}

Shibuya, Masatoshi ^{[1
]}

Kanoh, Naoki ^{[1
]}

Iwabuchi, Yoshiharu ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

来源：

CHEMISTRY LETTERS | 2008年 / 37卷 / 09期

关键词：

D O I：

10.1246/cl.2008.962

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient enantiocontrolled entry to Martinella alkaloids was achieved based on the unexpected discovery that a catalytic amount of KH/dicyclohexyl-18-crown-6 induced an intramolecular Mukaiyama-Mannich reaction of imine 3, leading to a cascade sequence involving, a novel silyl group migration to furnish the pyrroloquinoline core 6.

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页码：962 / 963

页数：2

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