Interferon Treatment for Hepatitis B

被引：82

作者：

Konerman, Monica A. ^{[1
]}

Lok, Anna S. ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 04期

关键词：

Chronic hepatitis B; Cirrhosis; Hepatocellular carcinoma; Hepatitis B e antigen; Hepatitis B surface antigen; Hepatitis B virus genotype; E-ANTIGEN SEROCONVERSION; RANDOMIZED CONTROLLED-TRIAL; HBEAG-NEGATIVE PATIENTS; TERM-FOLLOW-UP; PEGINTERFERON ALPHA-2A; PEGYLATED INTERFERON-ALPHA-2B; SURFACE-ANTIGEN; HEPATOCELLULAR-CARCINOMA; SUSTAINED RESPONSE; VIRUS INFECTION;

D O I：

10.1016/j.cld.2016.06.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis B virus (HBV) infection has a significant public health impact. There are currently 7 approved therapies for chronic HBV, including standard and pegylated interferon (IFN)-alpha, and 5 nucleos(t)ide analogs (NUCs). IFN offers benefits over NUCs, including a finite duration of therapy and a higher rate of clearance of hepatitis B e antigen and surface antigen. These benefits need to be weighed against the potential adverse effects of IFN therapy. Some patients should not receive IFN because of advanced liver disease or comorbidities. This article reviews the mechanisms of action, efficacy, and clinical use of IFN therapy for HBV infection.

引用

页码：645 / +

页数：22

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