Pharmaceutical and biomedical applications of enantioseparations using liquid chromatographic techniques

The chiral separation methods using liquid chromatographic techniques can be divided into two categories: one is a direct method, which is based on a diastereomer formation on stationary phase or in mobile phase. The other is an indirect method, which is based on a diasteromer formation by reaction with a homochiral reagent. The enantiomer separation on a chiral stationary phases followed by derivatization with an achiral reagent is also dealt with this review article as the indirect method. The pharmaceutical and biomedical applications of enantioseparations using the direct and indirect methods have been considered in this review. (C) 2002 Elsevier Science B.V. All rights reserved.