Antibiotic treatment of hidradenitis suppurativa

被引:11
作者
Revuz, J.
机构
来源
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE | 2012年 / 139卷 / 8-9期
关键词
Hidradenitis suppurativa; Antibiotics; Coagulase-negative staphylococci; Anaerobes; MACROLIDE ANTIBIOTICS; LONG-TERM; THERAPY; BACTERIOLOGY; CLINDAMYCIN; MECHANISMS; INFECTION; CULTURES;
D O I
10.1016/j.annder.2012.05.016
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Bacterial infection plays an important role in hidradenitis suppurativa (HS). This infection has a number of unique features: chronicity, absence of lymph node involvement, and absence in most cases of acute super-infection by Staphylococcus aureus and/or streptococci. Treatment is based mainly on antibiotics. Various bacteria are involved; they are often part of the resident flora and may combine in polymicrobial infections, and they consist mainly of two families: coagulase-negative staphylococci (CNS) and anaerobes. Numerous antibiotics are active against CNS: betalactamins, lincosamides, macrolides, rifampicin, tetracyclines and fluoroquinolones. Antibiotics active against anaerobes include metronidazole, betalactamins, lincosamides and one fluoroquinolone (moxifloxacine). Antibiotics are given per os and in combination. Treatment is usually long-term, with a frequent need for maintenance therapy. It ha; to be tailored to various clinical situations: intermittent development, in which "abortive" emergency treatment is used; major or major continuous forms, where combined antibiotics are used, most frequently rifampicin and clindamycin. The global treatment strategy involves a surgical approach, which can be aided but not replaced by antibiotics. While the risks of long-term antibiotic use are reduced in this specific population of "healthy" young adults, they are not absent. (C) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:532 / 541
页数:10
相关论文
共 38 条
[1]  
Adams DR, 2010, ARCH DERMATOL, V146, P501, DOI 10.1001/archdermatol.2010.72
[2]   Immunomodulatory Effects of Macrolide Antibiotics - Part 1: Biological Mechanisms [J].
Altenburg, J. ;
de Graaff, C. S. ;
van der Werf, T. S. ;
Boersma, W. G. .
RESPIRATION, 2011, 81 (01) :67-74
[3]   Immunomodulatory Effects of Macrolide Antibiotics - Part 2: Advantages and Disadvantages of Long-Term, Low-Dose Macrolide Therapy [J].
Altenburg, J. ;
de Graaff, C. S. ;
van der Werf, T. S. ;
Boersma, W. G. .
RESPIRATION, 2011, 81 (01) :75-87
[4]  
Batard E, 2006, THERAPEUTIQUE INFECT
[5]   Long-term results of acitretin therapy for hidradenitis suppurativa. Is acne inversa also a misnomer? [J].
Boer, J. ;
Nazary, M. .
BRITISH JOURNAL OF DERMATOLOGY, 2011, 164 (01) :170-175
[6]   Hidradenitis suppurativa:: are tumour necrosis factor-α blockers the ultimate alternative? [J].
Brunasso, A. M. G. ;
Delfino, C. ;
Massone, C. .
BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (03) :761-763
[7]   Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity [J].
Canoui-Poitrine, Florence ;
Revuz, Jean E. ;
Wolkenstein, Pierre ;
Viallette, Cedric ;
Gabison, Germaine ;
Pouget, Florence ;
Poli, Florence ;
Faye, Ousmane ;
Bastuji-Garin, Sylvie .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 61 (01) :51-57
[8]   TOPICAL TREATMENT OF HIDRADENITIS SUPPURATIVA WITH CLINDAMYCIN [J].
CLEMMENSEN, OJ .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 1983, 22 (05) :325-328
[9]   Immunomodulatory effects of quinolones [J].
Dalhoff, A ;
Shalit, L .
LANCET INFECTIOUS DISEASES, 2003, 3 (06) :359-371
[10]   How antibiotics can make us sick: the less obvious adverse effects of antimicrobial chemotherapy [J].
Dancer, SJ .
LANCET INFECTIOUS DISEASES, 2004, 4 (10) :611-619