Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

被引：12
|
作者：
Seenath, M. M. [2 ]
Roberts, D. [2 ]
Cawthorne, C. [2 ]
Saunders, M. P. [3 ]
Armstrong, G. R. [4 ]
O'Dwyer, S. T.
Stratford, I. J. [5 ]
Dive, C. [2 ,5 ,6 ]
Renehan, A. G. [1 ,2 ,6 ]
机构：
[1] Univ Manchester, Christie Hosp NHS Fdn Trust, Dept Surg, Manchester M20 4BX, Lancs, England
[2] Paterson Inst Canc Res, Manchester M20 9BX, Lancs, England
[3] Christie Hosp NHS Fdn Trust, Dept Clin Oncol, Manchester, Lancs, England
[4] Hope Hosp, Dept Histopathol, Salford M6 8HD, Lancs, England
[5] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M20 4BX, Lancs, England
[6] Univ Manchester, Sch Canc & Imaging Sci, Manchester M20 4BX, Lancs, England
来源：
BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 03期
基金：
英国医学研究理事会;
关键词：
colorectal cancer; tumour hypoxia; Bid; HIF-1; alpha;
D O I：
10.1038/sj.bjc.6604474
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1 alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1 alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression ( ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.
引用
收藏
页码：459 / 463
页数：5
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