Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

被引：12

作者：

Seenath, M. M. ^{[2
]}

Roberts, D. ^{[2
]}

Cawthorne, C. ^{[2
]}

Saunders, M. P. ^{[3
]}

Armstrong, G. R. ^{[4
]}

O'Dwyer, S. T.

Stratford, I. J. ^{[5
]}

Dive, C. ^{[2
,5
,6
]}

Renehan, A. G. ^{[1
,2
,6
]}

机构：

[1] Univ Manchester, Christie Hosp NHS Fdn Trust, Dept Surg, Manchester M20 4BX, Lancs, England

[2] Paterson Inst Canc Res, Manchester M20 9BX, Lancs, England

[3] Christie Hosp NHS Fdn Trust, Dept Clin Oncol, Manchester, Lancs, England

[4] Hope Hosp, Dept Histopathol, Salford M6 8HD, Lancs, England

[5] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M20 4BX, Lancs, England

[6] Univ Manchester, Sch Canc & Imaging Sci, Manchester M20 4BX, Lancs, England

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 03期

基金：

英国医学研究理事会;

关键词：

colorectal cancer; tumour hypoxia; Bid; HIF-1; alpha;

D O I：

10.1038/sj.bjc.6604474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1 alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1 alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression ( ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.

引用

页码：459 / 463

页数：5

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