The outcome and analysis of different treatments for solitary plasmacytoma of bone

Solitary plasmacytoma of the bone (SPB) is a malignant proliferation of plasma cells that occurs within the axial skeleton and is characterized by destruction of the bone. SPB generally occurs in the pelvis, femur, humerus, and rib. Currently, radiation therapy remains the primary choice of treatment for SPB, as plasmacytoma is a radiosensitive tumor. In this study, a total of 12 patients diagnosed with SPB were enrolled. Surgery was performed to all patients with SPB in combination with radiation therapy or chemotherapy, or both. The clinical outcomes were recorded and compared. Based on the follow-up data, no recurrence was observed in patients who received surgery and radiation therapy, or in those who received surgery with radiation therapy and chemotherapy. In conclusion, systematic therapy (surgery, radiation therapy, and chemotherapy) may be applied for the treatment of patients with SPB to obtain a better prognosis.