Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer

被引：100

作者：

Zheng, G

Li, H

Zhang, M

Lund-Katz, S

Chance, B

Glickson, JD

机构：

[1] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[3] Shanghai Univ, Dept Chem, Shanghai 200436, Peoples R China

[4] Childrens Hosp Philadelphia, Dept Pediat GI Nutr, Philadelphia, PA 19104 USA

来源：

BIOCONJUGATE CHEMISTRY | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1021/bc025516h

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.

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页码：392 / 396

页数：5

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