Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer

被引:98
作者
Zheng, G
Li, H
Zhang, M
Lund-Katz, S
Chance, B
Glickson, JD
机构
[1] Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[3] Shanghai Univ, Dept Chem, Shanghai 200436, Peoples R China
[4] Childrens Hosp Philadelphia, Dept Pediat GI Nutr, Philadelphia, PA 19104 USA
关键词
D O I
10.1021/bc025516h
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
To target tumors overexpressing low-density lipoprotein receptors (LDLr), a pyropheophorbide cholesterol oleate conjugate was synthesized and successfully reconstituted into the low-density lipoprotein (LDL) lipid core. Laser scanning confocal microscopy studies demonstrated that this photosensitizer-reconstituted LDL can be internalized via LDLr by human hepatoblastoma G(2) (HepG(2)) tumor cells.
引用
收藏
页码:392 / 396
页数:5
相关论文
共 19 条
[1]   THE EFFECTS OF PLASMA-LIPOPROTEINS ON INVITRO TUMOR-CELL KILLING AND INVIVO TUMOR PHOTOSENSITIZATION WITH BENZOPORPHYRIN DERIVATIVE [J].
ALLISON, BA ;
WATERFIELD, E ;
RICHTER, AM ;
LEVY, JG .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1991, 54 (05) :709-715
[2]  
Brown M S, 1980, Ann N Y Acad Sci, V348, P48, DOI 10.1111/j.1749-6632.1980.tb21290.x
[3]   INVITRO INTERACTION OF THE PHOTOACTIVE ANTICANCER PORPHYRIN DERIVATIVE PHOTOFRIN-II WITH LOW-DENSITY-LIPOPROTEIN, AND ITS DELIVERY TO CULTURED HUMAN-FIBROBLASTS [J].
CANDIDE, C ;
MORLIERE, P ;
MAZIERE, JC ;
GOLDSTEIN, S ;
SANTUS, R ;
DUBERTRET, L ;
REYFTMANN, JP ;
POLONOVSKI, J .
FEBS LETTERS, 1986, 207 (01) :133-138
[4]  
CRAIG IF, 1981, J LIPID RES, V22, P687
[5]   PROPERTIES OF INCORPORATION, REDISTRIBUTION, AND INTEGRITY OF PORPHYRIN LOW-DENSITY-LIPOPROTEIN COMPLEXES [J].
DESMIDT, PC ;
VERSLUIS, AJ ;
VANBERKEL, TJC .
BIOCHEMISTRY, 1993, 32 (11) :2916-2922
[6]   Photodynamic therapy [J].
Dougherty, TJ ;
Gomer, CJ ;
Henderson, BW ;
Jori, G ;
Kessel, D ;
Korbelik, M ;
Moan, J ;
Peng, Q .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905
[7]   LOW-DENSITY-LIPOPROTEIN AS A VEHICLE FOR TARGETING ANTITUMOR COMPOUNDS TO CANCER-CELLS [J].
FIRESTONE, RA .
BIOCONJUGATE CHEMISTRY, 1994, 5 (02) :105-113
[8]  
Henderson BW, 1997, CANCER RES, V57, P4000
[9]  
KRIEGER M, 1979, J BIOL CHEM, V254, P3845
[10]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265